ArticleNutrition (Burbank, Los Angeles County, Calif.)
Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells.
Article in Nutrition (Burbank, Los Angeles County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose.Nutrients · 2020Article
- The DESIGNER Approach Helps Decipher the Hypoglycemic Bioactive Principles ofJournal of natural products · 2019Article
- An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation.Molecular nutrition & food research · 2018Article
- An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.Frontiers in pharmacology · 2017Review
- Article
- Botanicals and translational medicine: a paradigm shift in research approach.Nutrition (Burbank, Los Angeles County, Calif.)Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAn increase in ectopic lipids in peripheral tissues has been implicated in attenuating insulin action. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is unknown. The aim of this study was to determine whether the mechanism by which the bioactive compounds in PMI 5011 improve insulin signaling is through regulation of ceramide metabolism.
methodsL6 Myotubes were separately preincubated with 250 μM palmitic acid with or without PMI 5011 or four bioactive compounds isolated from PMI 5011 and postulated to be responsible for the effect. The effects on insulin signaling, ceramide, and glucosylceramide profiles were determined.
resultsTreatment of L6 myotubes with palmitic acid resulted in increased levels of total ceramides and glucosylceramides, and cell surface expression of gangliosides. Palmitic acid also inhibited insulin-stimulated phosphorylation of protein kinase B/Akt and reduced glycogen accumulation. Bioactives from PMI 5011 had no effect on ceramide formation but one active compound (DMC-2) and its synthetic analog significantly reduced glucosylceramide accumulation and increased insulin sensitivity via restoration of Akt phosphorylation.
conclusionsThe observations suggest that insulin sensitization by PMI 5011 is partly mediated through moderation of glycosphingolipid accumulation.
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