ArticleNutrition (Burbank, Los Angeles County, Calif.)
Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice.
Article in Nutrition (Burbank, Los Angeles County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- The Effect of Soy Protein-Phycocyanin Concentrate Complex Treatment on Biomarkers of HDL Functional Properties in Male Wistar Rats.Current issues in molecular biology · 2026Article
- Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans: a meta-omics study.NPJ science of food · 2025Article
- Polyphenols and metabolism: from present knowledge to future challenges.Journal of physiology and biochemistry · 2024Review
- Immunomodulation Induced in BALB/c Mice after Subacute Exposure to Hydroalcoholic Extract ofCurrent drug discovery technologies · 2024Article
- Covalent polyphenols-proteins interactions in food processing: formation mechanisms, quantification methods, bioactive effects, and applications.Frontiers in nutrition · 2024Review
- Metallothionein-Kidney Bean Polyphenol Complexes Showed Antidiabetic Activity in Type 2 Diabetic Rats by Improving Insulin Resistance and Regulating Gut Microbiota.Foods (Basel, Switzerland) · 2023Article
- Soy Protein Isolate Interacted with Acrylamide to Reduce the Release of Acrylamide in the In Vitro Digestion Model.Foods (Basel, Switzerland) · 2023Article
- Article
- Evaluation of Different Advanced Approaches to Simulation of Dynamic In Vitro Digestion of Polyphenols from Different Food Matrices-A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols.Plant foods for human nutrition (Dordrecht, Netherlands) · 2022Article
- Designing a Clinical Study With Dietary Supplements: It's All in the Details.Frontiers in nutrition · 2021Article
- The DESIGNER Approach Helps Decipher the Hypoglycemic Bioactive Principles ofJournal of natural products · 2019Article
- Interaction between rice bran albumin and epigallocatechin gallate and their physicochemical analysis.Food science and biotechnology · 2018Article
- An Extract ofOxidative medicine and cellular longevity · 2018Article
- An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.Frontiers in pharmacology · 2017Review
- Interactions of β-Conglycinin (7S) with Different Phenolic Acids-Impact on Structural Characteristics and Proteolytic Degradation of Proteins.International journal of molecular sciences · 2016Article
- Comparison of soymilk and probiotic soymilk effects on serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in diabetic Wistar rats.ARYA atherosclerosis · 2015Article
- Botanicals and translational medicine: a paradigm shift in research approach.Nutrition (Burbank, Los Angeles County, Calif.)Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveScientifically validated food-based interventions are a practical means of addressing the epidemic of metabolic syndrome. An ethanolic extract of Artemisia dracunculus L. (PMI-5011) containing bioactive polyphenols, such as 2', 4'-dihydroxy-4-methoxydihydrochalcone (DMC-2), improved insulin resistance in vitro and in vivo. Plant polyphenols are concentrated and stabilized when complexed to protein-rich matrices, such as soy protein isolate (SPI), which act as effective food-based delivery vehicles. The aim of this study was to compare the bioaccessibility, bioavailability, and efficacy of polyphenols extracted from A. dracunculus and delivered as PMI-5011 (ethanolic extract alone), formulated with the non-food excipient Gelucire(®), (5011- Gelucire), or sorbed to SPI (5011-Nutrasorb(®)).
methodsPMI-5011, 5011-Gelucire or 5011-Nutrasorb each containing 162 μg of DMC-2 was delivered to the TNO intestinal model-1 of the human upper gastrointestinal tract to compare the effect of delivery vehicle on DMC-2 bioaccessibility. C57BL6/J mice were orally administered 5011-Nutrasorb or PMI-5011 to compare effects of polyphenol-protein complexation on acute hypoglycemic activity and bioavailability of DMC-2 in serum.
resultsAt 500 mg/kg, 5011-Nutrasorb and PMI-5011 had similar hypoglycemic activity in a high-fat diet-induced diabetes mouse model despite the fact that 5011-Nutrasorb delivered 15 times less DMC-2 (40 versus 600 μg/kg). This can be partially explained by eight times greater DMC-2 absorption into serum from 5011-Nutrasorb than from PMI-5011. TNO intestinal model-1 experiments confirmed higher total bioaccessibility of DMC-2 in vitro when delivered in 5011-Nutrasorb (50.2%) or Gelucire-5011 (44.4%) compared with PMI-5011 (27.1%; P = 0.08).
conclusionComplexation with soy protein makes antidiabetic A. dracunculus polyphenols more bioavailable and bioaccessible.
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