ArticleThe Journal of comparative neurology2014
The orexinergic neurons receive synaptic input from C1 cells in rats.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Hypothalamic Glutamatergic/Orexinergic Neurons Attenuate Fentanyl-Induced Respiratory Depression via Medullary Pre-BöTzinger Complex Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat.The Journal of comparative neurology · 2026Article
- Impact of Circadian Rhythm and Sleep Architecture Changes on Prognosis in Patients with Acute Hemorrhagic Stroke.Nature and science of sleep · 2025Article
- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments.Handbook of experimental pharmacology · 2024Review
- Analysis of the distribution of vagal afferent projections from different peripheral organs to the nucleus of the solitary tract in rats.The Journal of comparative neurology · 2022Article
- The psychophysiology of the sigh: I: The sigh from the physiological perspective.Biological psychology · 2022Review
- The sigh and related behaviors.Handbook of clinical neurology · 2022Review
- Differential Contribution of the Retrotrapezoid Nucleus and C1 Neurons to Active Expiration and Arousal in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus.Molecular metabolism · 2020Article
- Hindbrain glucoregulatory mechanisms: Critical role of catecholamine neurons in the ventrolateral medulla.Physiology & behavior · 2019Review
- Orexins, Sleep, and Blood Pressure.Current hypertension reports · 2018Review
- C1 neurons: a nodal point for stress?Experimental physiology · 2018Review
- Role of Orexin-A in Hypertension and Obesity.Current hypertension reports · 2017Review
- Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Orexin and Central Modulation of Cardiovascular and Respiratory Function.Current topics in behavioral neurosciences · 2017Review
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- Intrathecal Intermittent Orexin-A Causes Sympathetic Long-Term Facilitation and Sensitizes the Peripheral Chemoreceptor Response to Hypoxia in Rats.The Journal of pharmacology and experimental therapeutics · 2016Article
- The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.Scientific reports · 2016Article
- A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats.Brain research · 2015Article
- Catecholaminergic neurons projecting to the paraventricular nucleus of the hypothalamus are essential for cardiorespiratory adjustments to hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The C1 cells, located in the rostral ventrolateral medulla (RVLM), are activated by pain, hypoxia, hypoglycemia, infection, and hypotension and elicit cardiorespiratory stimulation, adrenaline and adrenocorticotropic hormone (ACTH) release, and arousal. The orexin neurons contribute to the autonomic responses to acute psychological stress. Here, using an anatomical approach, we consider whether the orexin neurons could also be contributing to the autonomic effects elicited by C1 neuron activation. Phenylethanolamine N-methyl transferase-immunoreactive (PNMT-ir) axons were detected among orexin-ir somata, and close appositions between PNMT-ir axonal varicosities and orexin-ir profiles were observed. The existence of synapses between PNMT-ir boutons labeled with diaminobenzidine and orexinergic neurons labeled with immunogold was confirmed by electron microscopy. We labeled RVLM neurons with a lentiviral vector that expresses the fusion protein ChR2-mCherry under the control of the catecholaminergic neuron-selective promoter PRSx8 and obtained light and ultrastructural evidence that these neurons innervate the orexin cells. By using a Cre-dependent adeno-associated vector and TH-Cre rats, we confirmed that the projection from RVLM catecholaminergic neurons to the orexinergic neurons originates predominantly from PNMT-ir catecholaminergic (i.e., C1 cells). The C1 neurons were found to establish predominantly asymmetric synapses with orexin-ir cell bodies or dendrites. These synapses were packed with small clear vesicles and also contained dense-core vesicles. In summary, the orexin neurons are among the hypothalamic neurons contacted and presumably excited by the C1 cells. The C1-orexin neuronal connection is probably one of several suprabulbar pathways through which the C1 neurons activate breathing and the circulation, raise blood glucose, and facilitate arousal from sleep.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.