ReviewInternational orthopaedics2014
Induced membrane for treatment of critical sized bone defect: a review of experimental and clinical experiences.
Review in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Induced membrane spontaneous osteogenesis leading to tibiofibular fusion: a study of case series and literature review.BMC musculoskeletal disorders · 2026Pooled it
- PET/CT-guided navigation-assisted debridement for tibial fracture-related infection: a retrospective cohort study.Journal of orthopaedic translation · 2026Article
- A composite hydrogel enables the spatiotemporal delivery of distinct cytokines to drive the native vascularized bone regeneration.Bioactive materials · 2026Article
- Don't judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good.npj biomedical innovations · 2026Review
- Modified masquelet technique coupled with vascularized fibular transplantation (transposition) in the reconstruction of ultra-long structural bone defects following osteomyelitis debridement: clinical application and preliminary study on therapeutic outcomes.BMC musculoskeletal disorders · 2025Article
- A review of the Masquelet technique in the treatment of lower limb critical-size bone defects.Annals of the Royal College of Surgeons of England · 2025Review
- Optimisation and Validation of an Induced Membrane Technique Model to Assess Bone Regeneration in Rats.Journal of tissue engineering and regenerative medicine · 2025Article
- The Masquelet induced membrane technique with PRP-FG-nHA/PA66 scaffold can heal a rat large femoral bone defect.BMC musculoskeletal disorders · 2024Article
- Review
- Surgical repair of large segmental bone loss with the induced membrane technique: patient reported outcomes are comparable to nonunions without bone loss.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Nacre-mimetic cerium-doped nano-hydroxyapatite/chitosan layered composite scaffolds regulate bone regeneration via OPG/RANKL signaling pathway.Journal of nanobiotechnology · 2023Article
- Questions about Using the Induced Membrane Technique to Manage Cases of Congenital Tibial Pseudarthrosis.Cells · 2023Article
- 3D-Printed Bioactive Scaffold Loaded with GW9508 Promotes Critical-Size Bone Defect Repair by Regulating Intracellular Metabolism.Bioengineering (Basel, Switzerland) · 2023Article
- Modified Masquelet technique in children.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022Article
- Effects of PMMA spacer loaded with varying vancomycin concentrations on bone regeneration in the Masquelet technique.Scientific reports · 2022Article
- Article
- SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect.Journal of bone and mineral metabolism · 2021Article
- Expression of VEGF in Peripheral Serum Is a Possible Prognostic Factor in Bone-Regeneration via Masquelet-Technique-A Pilot Study.Journal of clinical medicine · 2021Article
- Cambridge experience in spontaneous bone regeneration after traumatic segmental bone defect: a case series and review of literature.BMJ case reports · 2020Review
- Management of Infected Bone Defects of the Lower Extremities by Three-Stage Induced Membrane Technique.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to review experimental and clinical experiences about the use of an induced membrane to address critical bone size defect of the limbs.
methodsFrom a review of published experimental and clinical data and from our clinical experience, we present the key data about the use of an induced membrane to address critical bone size defect of the limbs.
resultsAfter reviewing the concept of critical sized bone defect, we present the different indications of an induced membrane, the key points of the surgical technique and the strategy of bone grafting given the indication, localization and importance of the critical sized bone defect. Finally, we discuss the perspective of the use of an induced membrane with various bone substitutes.
conclusionsThe use of an induced membrane to treat critical sized bone defects of the limbs is a simple, reliable and reproducible technique. Certain technical steps should be pointed out and observed with great caution in order to avoid any pitfalls. This technique will probably be a key step for facilitating bone inclusion of new bone substitutes proposed by recent bioengineering.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.