Evidence map›Paper›PMID 24984259›Full record

ArticleDevelopmental biology2014

Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development.

Marcus-Oliver Schupp, Matthew Waas, Chang-Zoon Chun, Ramani Ramchandran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marcus-Oliver SchuppMedical College of Wisconsin, Department of Pediatrics, CRI Developmental Vascular Biology Program, Translational and Biomedical Research Center, CRI C3420, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226, USA.
Matthew WaasDivision of Nephrology, Hypertension and Renal Transplantation, Room CG-98, 1600 Archer Road, University of Florida, Gainesville, FL 32610, USA.
Chang-Zoon ChunMedical College of Wisconsin, Department of Pediatrics, CRI Developmental Vascular Biology Program, Translational and Biomedical Research Center, CRI C3420, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226, USA; Division of Nephrology, Hypertension and Renal Transplantation, Room CG-98, 1600 Archer Road, University of Florida, Gainesville, FL 32610, USA.
Ramani RamchandranMedical College of Wisconsin, Department of Pediatrics, CRI Developmental Vascular Biology Program, Translational and Biomedical Research Center, CRI C3420, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226, USA. Electronic address: rramchan@mcw.edu.
Medical College of Wisconsin · USUniversity of Florida · US

Funding

Targeting DUSP-5 to Treat Vascular AnomaliesR01HL112639 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2012 to 2016
$2.6M
Roundabout4 signaling in endothelial cellsR01HL090712 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2009 to 2012
$1.8M
Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebratesR01HL102745 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2011 to 2014
$1.5M
NHLBI NIH HHS HL090712NHLBI NIH HHS HL102745NHLBI NIH HHS HL112639NHLBI NIH HHS R01 HL090712NHLBI NIH HHS R01 HL102745NHLBI NIH HHS R01 HL112639
6 · The paper itself

Abstract

E-twenty six variant 2 (Etv2) transcription factor participates in cardiac, vascular-endothelial and blood cell lineage specification decisions during embryonic development. Previous studies have identified genomic elements in the etv2 locus responsible for vascular endothelial cell specification. Using transgenic analysis in zebrafish, we report here an etv2 proximal promoter fragment that prevents transgene misexpression in myocardial progenitor cells. This inhibition of etv2 expression in the cardiac progenitor population is partly mediated by Scl and Nkx2.5, likely through direct binding to the etv2 promoter, and cis-regulatory elements located in the first and second introns. The results identify an etv2 cis-regulatory mechanism controlling cardiovascular fate choice implying that etv2 participates in a transcriptional network mediating developmental plasticity of endothelial progenitor cells during embryonic development.

Indexed as

AnimalsAnimals, Genetically ModifiedBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineCell LineageEmbryonic Stem CellsEndothelial CellsEndothelium, VascularErythrocytesGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene SilencingHeartHomeobox Protein Nkx-2.5MorpholinosBasic Helix-Loop-Helix ProteinsEtv2 protein, zebrafishHomeobox Protein Nkx-2.5MorpholinosNkx2.5 protein, zebrafishProto-Oncogene Proteinstal1 protein, zebrafishT-Cell Acute Lymphocytic Leukemia Protein 1Transcription FactorsZebrafish ProteinsCardiac discEtv2SclTranscriptionZebrafish

Identifiers

PMID24984259
PMCPMC4137469
OpenAlexW2017000118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.