ArticleMedical care2014
Evidence of sample use among new users of statins: implications for pharmacoepidemiology.
Article in Medical care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of methods for determining cross-sectional active medications using pharmacy databases.Pharmacoepidemiology and drug safety · 2019Pooled it
- Influencers of generic drug utilization: A systematic review.Research in social & administrative pharmacy : RSAP · 2018Pooled it
- The Association Between Patient Sociodemographic Characteristics and Generic Drug Use: A Systematic Review and Meta-analysis.Journal of managed care & specialty pharmacy · 2018Pooled it
- Comparison of measures of medication adherence from pharmacy dispensing and insurer claims data.Health services research · 2022Article
- Effect of Initiating Cardiac Rehabilitation After Myocardial Infarction on Subsequent Hospitalization in Older Adults.Journal of cardiopulmonary rehabilitation and prevention · 2020Article
- Methodological considerations when analysing and interpreting real-world data.Rheumatology (Oxford, England) · 2020Article
- Bias in pharmacoepidemiologic studies using secondary health care databases: a scoping review.BMC medical research methodology · 2019Article
- Approaches to Address Premature Death of Patients When Assessing Patterns of Use of Health Care Services After an Index Event.Medical care · 2018Article
- Examining Parental Medication Adherence as a Predictor of Child Medication Adherence in Pediatric Anxiety Disorders.Medical care · 2018Article
- Injection testosterone and adverse cardiovascular events: A case-crossover analysis.Clinical endocrinology · 2018Article
- Primary non-adherence and the new-user design.Pharmacoepidemiology and drug safety · 2018Article
- Predictors of prevalent statin use among older adults identified as statin initiators based on Medicare claims data.Pharmacoepidemiology and drug safety · 2016Article
- Low-Cost Generic Program Use by Medicare Beneficiaries: Implications for Medication Exposure Misclassification in Administrative Claims Data.Journal of managed care & specialty pharmacy · 2016Article
- Predicting persistence to antidepressant treatment in administrative claims data: Considering the influence of refill delays and prior persistence on other medications.Journal of affective disorders · 2016Article
- Comparison of diagnostic evaluations for cough among initiators of angiotensin converting enzyme inhibitors and angiotensin receptor blockers.Pharmacoepidemiology and drug safety · 2016Article
- Use of Prescription Drug Samples in the USA: A Descriptive Study with Considerations for Pharmacoepidemiology.Drug safety · 2016Article
- Prevalence of Low-Cost Generic Program Use in a Nationally Representative Cohort of Privately Insured Adults.Journal of managed care & specialty pharmacy · 2015Article
- Dynamics of cinacalcet use and biochemical control in hemodialysis patients: a retrospective New-user cohort design.BMC nephrology · 2015Article
- Predictors of gastrointestinal bleeding among patients with atrial fibrillation after initiating dabigatran therapy.Pharmacotherapy · 2015Article
- Factors driving anticoagulant selection in patients with atrial fibrillation in the United States.The American journal of cardiology · 2015Article
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Funding
Abstract
backgroundEpidemiologic studies of prescription medications increasingly rely on large administrative health care databases. These data do not capture patients' use of medication samples. This could potentially bias studies of short-term effects where date of initiation may be inaccurate.
objectivesTo assess the extent of sample use among patients initiating statin therapy. RESEARCH
designRetrospective cohort of patients who filled a first prescription for a statin after at least 6 months of statin-free period in 2007-2010. Low-density lipoprotein (LDL) values obtained within the 15 days preceding the first prescription were analyzed using a 2-component Gaussian mixture model to look for evidence of prior treatment. SUBJECTS: A total of 26,033 statin initiators with at least 1 LDL laboratory result within the 15 days preceding the prescription fill. MEASURES: Estimators for the proportion of patients filling a new prescription already on treatment.
resultsAmong 9256 patients filling a branded statin, LDL distribution was bimodal, consisting of 2 Gaussian distributions: one, which made up 13.4% of the total population, had much lower LDL values (mean=71.8 mg/dL) compared with the second (mean=148.0 mg/dL), suggesting drug use before first dispensed prescription. Among 16,777 patients filling a generic statin, LDL levels were substantially higher with no evidence of bimodality that would suggest prior sample use.
conclusionsThese results provide indirect evidence that the initial period of branded medication use may often be missed when using pharmacy claims data to define drug initiation. Further research is needed to examine approaches to better identify incident medication use when assessing short-term effects.
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