Evidence map›Paper›PMID 24984189›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2014

Superior outcomes and lower outpatient costs with scale-up of antiretroviral therapy at the GHESKIO clinic in Port-au-Prince, Haiti.

Cynthia Riviere, Elizabeth Faust, Thane Miller, Eduard J Beck, Elaine Baruwa, Patrice Severe, Karine Severe, Claudia Thomas Riché, Rachelle Cassagnol, Sidney Atwood and 5 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cynthia Riviere*Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti; †Analysis Group, Boston, MA; ‡Massachusetts Institute of Technology, Cambridge, MA; §London School of Hygiene and Tropical Medicine, London, United Kingdom; ‖Abt Associates, Cambridge, MA; ¶Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA; #Weill Cornell Medical College, New York, NY; and **Center for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY.
Elizabeth Faust
Thane Miller
Eduard J Beck
Elaine Baruwa
Patrice Severe
Karine Severe
Claudia Thomas Riché
Rachelle Cassagnol
Sidney Atwood
Morgan Esperance
Lauren Webster
Pierre Cremieux
Jean W Pape
Serena P Koenig

Funding

GHESKIO HIV Clinical Trial UnitUM1AI069421 · NIAID · GHESKIO CENTER · PI JEAN WILLIAM PAPE · 2012 to 2026
$23.6M
GHESKIO HIV Clinical Trial UnitU01AI069421 · NIAID · GHESKIO CENTER · PI PAPE, JEAN WILLIAM · 2007 to 2011
$8.4M
Haiti AIDS Research Training: Models to ImplementationU2RTW006896 · FIC · GHESKIO CENTER · PI PAPE, JEAN WILLIAM · 2004 to 2013
$5.1M
Same-Day HIV Testing and Treatment Initiation to Improve Retention in CareR01AI104344 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOENIG, SERENA PATRICIA · 2013 to 2015
$1.9M
Research training to improve ART adherence among HIV-infected adolescents in HaitiD43TW009606 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W · 2013 to 2017
$1.6M
FIC NIH HHS TW009606FIC NIH HHS U2R TW006896NIAID NIH HHS R01 AI104344NIAID NIH HHS R01AI104344-01A1NIAID NIH HHS UM1 AI069421
6 · The paper itself

Abstract

backgroundTreatment protocols and prices of antiretroviral therapy (ART) have changed over time. Yet, limited data exist to evaluate the impact of these changes on patient outcomes and treatment costs in resource-poor settings.

methodsWe compared patient-level data on outcomes, utilization, and cost for the first 2 years of ART for a cohort of adult patients initiating ART in 2003-2004 and a cohort initiating ART in 2006-2008 at the Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections clinic (GHESKIO) in Port-au-Prince, Haiti. Costs were measured from the health center perspective. Multivariate analyses were conducted to account for the potential impact of differences in disease severity at baseline.

resultsWith the exclusion of patients who transferred care, 92% (167/181) of patients in the 2006-2008 cohort and 75% (150/200) in the 2003-2004 cohort were alive and in care at the end of the study period. The mean cost per patient for the 2-year study period was US$723 for the 2006-2008 cohort vs. US$1191 for the 2003-2004 cohort, a cost difference of US$468 (P < 0.0001). The mean cost per patient alive and in care at the end of the 2-year study period was US$744 for the 2006-2008 cohort vs. US$1489 for the 2003-2004 cohort (P < 0.0001).

conclusionsHIV treatment outcomes in Haiti have improved over time while treatment costs declined by over 50% per patient alive and in care at the end of the 2-year study period. The major drivers in the reduction of treatment costs were the lower price of ART, lower costs for laboratory testing, and lower overhead costs.

Indexed as

Health Care CostsAdultAmbulatory Care FacilitiesAnti-HIV AgentsCohort StudiesDrug Administration ScheduleDrug Therapy, CombinationFemaleHaitiHIV InfectionsHumansMaleMiddle AgedTime FactorsTreatment OutcomeAnti-HIV Agents

Identifiers

PMID24984189
PMCPMC4277186

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.