ReviewDevelopmental and comparative immunology2014
Immune-directed support of rich microbial communities in the gut has ancient roots.
Review in Developmental and comparative immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Prophage regulation ofeLife · 2025Article
- Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Effects of Concentrate Feeding Sequence on Growth Performance, Nutrient Digestibility, VFA Production, and Fecal Microbiota of Weaned Donkeys.Animals : an open access journal from MDPI · 2023Article
- Environmental stress and nanoplastics' effects onFrontiers in immunology · 2023Article
- Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology.Immunogenetics · 2022Review
- Multiple sclerosis and the microbiota: Progress in understanding the contribution of the gut microbiome to disease.Evolution, medicine, and public health · 2022Review
- The Implication ofMicroorganisms · 2021Article
- Reflections on the Use of an Invertebrate Chordate Model System for Studies of Gut Microbial Immune Interactions.Frontiers in immunology · 2021Review
- Diversity, Bioactivity Profiling and Untargeted Metabolomics of the Cultivable Gut Microbiota ofMarine drugs · 2020Article
- Gut Microbiomes of the Eastern Oyster (mSphere · 2019Article
- Enchained growth and cluster dislocation: A possible mechanism for microbiota homeostasis.PLoS computational biology · 2019Article
- A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains.Frontiers in immunology · 2019Article
- Ocean warming alters predicted microbiome functionality in a common sea urchin.Proceedings. Biological sciences · 2018Article
- Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis.Biology open · 2018Article
- Cooperation and cheating as innovation: insights from cellular societies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Immunity in Protochordates: The Tunicate Perspective.Frontiers in immunology · 2017Review
- Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria.Nature communications · 2016Article
- Beyond 16S rRNA Community Profiling: Intra-Species Diversity in the Gut Microbiota.Frontiers in microbiology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The animal gut serves as a primary location for the complex host-microbe interplay that is essential for homeostasis and may also reflect the types of ancient selective pressures that spawned the emergence of immunity in metazoans. In this review, we present a phylogenetic survey of gut host-microbe interactions and suggest that host defense systems arose not only to protect tissue directly from pathogenic attack but also to actively support growth of specific communities of mutualists. This functional dichotomy resulted in the evolution of immune systems much more tuned for harmonious existence with microbes than previously thought, existing as dynamic but primarily cooperative entities in the present day. We further present the protochordate Ciona intestinalis as a promising model for studying gut host-bacterial dialogue. The taxonomic position, gut physiology and experimental tractability of Ciona offer unique advantages in dissecting host-microbe interplay and can complement studies in other model systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.