Evidence map›Paper›PMID 24984031›Full record

ArticleAnalytical chemistry2014

In vivo analytical performance of nitric oxide-releasing glucose biosensors.

Robert J Soto, Benjamin J Privett, Mark H Schoenfisch

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Robert J SotoDepartment of Chemistry, University of North Carolina at Chapel Hill , CB 3290, Chapel Hill, North Carolina 27599, United States.
Benjamin J Privett
Mark H Schoenfisch
University of North Carolina at Chapel Hill · USDurham University · GB

Funding

Nitric Oxide-Releasing Glucose BiosensorsR01EB000708 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHOENFISCH, MARK H · 2002 to 2011
$3.1M
Improving Host Response to Implantable Glucose Sensors via Nitric Oxide ReleaseR43DK093119 · NIDDK · NOVAN, INC. · PI PRIVETT, BENJAMIN JOSEPH, SCHOENFISCH, MARK H · 2011 to 2012
$987k
NIBIB NIH HHS R01 EB000708NIDDK NIH HHS R43 DK093119NIDDK NIH HHS R43DK093119
6 · The paper itself

Abstract

The in vivo analytical performance of percutaneously implanted nitric oxide (NO)-releasing amperometric glucose biosensors was evaluated in swine for 10 d. Needle-type glucose biosensors were functionalized with NO-releasing polyurethane coatings designed to release similar total amounts of NO (3.1 μmol cm(-2)) for rapid (16.0 ± 4.4 h) or slower (>74.6 ± 16.6 h) durations and remain functional as outer glucose sensor membranes. Relative to controls, NO-releasing sensors were characterized with improved numerical accuracy on days 1 and 3. Furthermore, the clinical accuracy and sensitivity of rapid NO-releasing sensors were superior to control and slower NO-releasing sensors at both 1 and 3 d implantation. In contrast, the slower, extended, NO-releasing sensors were characterized by shorter sensor lag times (<4.2 min) in response to intravenous glucose tolerance tests versus burst NO-releasing and control sensors (>5.8 min) at 3, 7, and 10 d. Collectively, these results highlight the potential for NO release to enhance the analytical utility of in vivo glucose biosensors. Initial results also suggest that this analytical performance benefit is dependent on the NO-release duration.

Indexed as

AnimalsBiosensing TechniquesBlood GlucoseGlucoseNanoparticlesNitric OxideNitric Oxide DonorsPolyurethanesProstheses and ImplantsSensitivity and SpecificitySus scrofaBlood GlucoseGlucoseNitric OxideNitric Oxide DonorsPolyurethanes

Identifiers

PMID24984031
PMCPMC4116185
OpenAlexW2070086206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.