Trial reportPloS one2014
Decreased miR-204 in H. pylori-associated gastric cancer promotes cancer cell proliferation and invasion by targeting SOX4.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Salivary MicroRNA for Diagnosis of Cancer and Systemic Diseases: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Review
- Non-coding RNAs in bladder cancer, a bridge between gut microbiota and host?Frontiers in immunology · 2024Review
- Function of Non-coding RNA inFrontiers in molecular biosciences · 2021Review
- High Expression of miR-204 in Chicken Atrophic Ovaries Promotes Granulosa Cell Apoptosis and Inhibits Autophagy.Frontiers in cell and developmental biology · 2020Article
- Retraction: Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4.PloS one · 2020Article
- MicroRNA-204 as an Indicator of Severity of Pulmonary Hypertension in Children with Congenital Heart Disease Complicated with Pulmonary Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- BCYRN1 is correlated with progression and prognosis in gastric cancer.Bioscience reports · 2019Article
- Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network.Briefings in bioinformatics · 2019Review
- Downregulation of microRNA-204 increases the expression of matrix metallopeptidase 9 in pediatric patients with pulpitis andExperimental and therapeutic medicine · 2019Article
- MicroRNA‑199a‑5p suppresses migration and invasion in oral squamous cell carcinoma through inhibiting the EMT‑related transcription factor SOX4.International journal of molecular medicine · 2019Article
- Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers.Journal of Cancer · 2019Article
- Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.American journal of cancer research · 2019Article
- An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer.Cell death and differentiation · 2018Article
- Systematic analysis of lncRNA-miRNA-mRNA competing endogenous RNA network identifies four-lncRNA signature as a prognostic biomarker for breast cancer.Journal of translational medicine · 2018Article
- MicroRNA-204 inhibits cell migration and invasion in human cervical cancer by regulating transcription factor 12.Oncology letters · 2018Article
- MicroRNA mediated regulation of immunity against gram-negative bacteria.International reviews of immunology · 2017Review
- SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population.Cancer cell international · 2017Article
- Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients.BioMed research international · 2017Article
- Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer.Scientific reports · 2016Article
Corrections and comments
- Retraction · 2020-10-22Duplication of/in Image · Error in Image · Lack of IRB/IACUC Approval and/or Compliance ·
- Erratum issued
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe molecular mechanism between Helicobacter pylori (H. pylori) infection and gastric cancer remained largely unknown. In this study, we determined the role of miRNA in H. pylori induced gastric cancer. METHODS AND
resultsWe found that miR-204 was decreased in H. pylori positive tissues by qRT-PCR. Knockdown of miR-204 enhanced the invasion and proliferation ability of gastric cancer cells in vitro. Luciferase assay revealed that SOX4 was target gene of miR-204, which was found up-regulated in H. pylori positive tissues. Down-regulation of miR-204 and over-expression of SOX4 promoted epithelial-mesenchymal transition process.
conclusionTaken together, our findings demonstrated that miR-204 may act as a tumor suppressor in H. pylori induced gastric cancer by targeting SOX4.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.