Trial reportPloS one2014
Dissociation of regional activity in default mode network in medication-naive, first-episode somatization disorder.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies.NeuroImage. Clinical · 2016Pooled it
- Functional brain abnormalities in patients with somatic symptom disorder presenting with chest pain: a resting-state fMRI study.Scientific reports · 2026Article
- Somatic symptoms mediate the association between subclinical anxiety and depressive symptoms and its neuroimaging mechanisms.BMC psychiatry · 2022Article
- Effects of Methylphenidate on Somatic Symptoms and Brain Functional Connectivity in Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- A Longitudinal Study on Attenuated Structural Covariance in Patients With Somatic Symptom Disorder.Frontiers in psychiatry · 2022Article
- Abnormal regional homogeneity and its relationship with symptom severity in cervical dystonia: a rest state fMRI study.BMC neurology · 2021Article
- Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms.Frontiers in psychiatry · 2021Article
- Briquet syndrome revisited: implications for functional neurological disorder.Brain communications · 2020Review
- Enhanced Connectivity of Thalamo-Cortical Networks in First-Episode, Treatment-Naive Somatization Disorder.Frontiers in psychiatry · 2020Article
- Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study.Clinical oral investigations · 2019Article
- Reduced Brain Activity in the Right Putamen as an Early Predictor for Treatment Response in Drug-Naive, First-Episode Schizophrenia.Frontiers in psychiatry · 2019Article
- Somatic symptoms disorders in Parkinson's disease are related to default mode and salience network dysfunction.NeuroImage. Clinical · 2019Article
- Increased Nucleus Accumbens Connectivity in Resting-State Patients With Drug-Naive, First-Episode Somatization Disorder.Frontiers in psychiatry · 2019Article
- Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder.Frontiers in psychiatry · 2018Article
- Precuneus abnormalities in middle-aged to older adults with depressive symptoms: An analysis of BDI-II symptom dimensions.Psychiatry research. Neuroimaging · 2017Article
- Article
- Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with somatization disorder (SD) have altered neural activity in the brain regions of the default mode network (DMN). However, the regional alteration of the DMN in SD remains unknown. The present study was designed to investigate the regional alterations of the DMN in patients with SD at rest.
methodsTwenty-five first-episode, medication-naive patients with SD and 28 age-, sex-, education- matched healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI) scan. The fractional amplitude of low-frequency fluctuations (fALFF) was applied to analyze the data.
resultsPatients with SD showed a dissociation pattern of resting-state fALFF in the DMN, with increased fALFF in the bilateral superior medial prefrontal cortex (MPFC, BA8, 9) and decreased fALFF in the left precuneus (PCu, BA7). Furthermore, significantly positive correlation was observed between the z values of the voxels within the bilateral superior MPFC and somatization subscale scores of the Symptom Check List (SCL-90) in patients with SD.
conclusionsOur findings indicate that there is a dissociation pattern of the anterior and posterior DMN in first-episode, treatment-naive patients with SD. The results provide new insight for the importance of the DMN in the pathophysiology of SD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.