Evidence map›Paper›PMID 24983941›Full record

SynthesisPloS one2014

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

Wenbo Tang, Matthew Kowgier, Daan W Loth, María Soler Artigas, Bonnie R Joubert, Emily Hodge, Sina A Gharib, Albert V Smith, Ingo Ruczinski, Vilmundur Gudnason and 71 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  11. Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023
    Review
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  18. Article
  19. Genetics of COPD.Annual review of physiology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

81 authors at 20 institutions in 11 countries.

Wenbo TangDivision of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America.
Matthew KowgierOntario Institute for Cancer Research and Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Daan W LothDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Healthcare Inspectorate, The Hague, the Netherlands.
María Soler ArtigasUniversity of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, United Kingdom; National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
Bonnie R JoubertEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America.
Emily HodgeDivision of Respiratory Medicine, University Hospital of Nottingham, Nottingham, United Kingdom.
Sina A GharibComputational Medicine Core, Center for Lung Biology, Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Ingo RuczinskiDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
Rasika A MathiasDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
Tamara B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Nadia N HanselDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Kathleen C BarnesDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.
Joyanna G HansenDivision of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Melinda C AldrichDepartment of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Michael AllerhandCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
R Graham BarrDivision of General Medicine, Pulmonary, Allergy and Critical Care, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
Guy G BrusselleDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Respiratory Medicine, Erasmus Medical Center, Rotterdam, the Netherlands; 22 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
David J CouperDivision of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America.
Ivan CurjuricSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Medical Genetics Section, University of Edinburgh Molecular Medicine Centre and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Josée DupuisBiostatistics Department, Boston University School of Public Health, Boston, Massachusetts, United States of America; The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America.
Tove FallDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Millennia FoyInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Nora FranceschiniGillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Wei GaoBiostatistics Department, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Sven GläserDepartment of Internal Medicine B; Pneumology, Cardiology, Intensive Care Medicine; Field of Research: Pneumology and Pneumological Epidemiology, University Medicine Greifswald, Greifswald, Germany.
Xiangjun GuInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Dana B HancockEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America; Behavioral Health Epidemiology Program, Research Triangle Institute, Research Triangle Park, North Carolina, United States of America.
Joachim HeinrichInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany and Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Rotterdam, the Netherlands.
Medea ImbodenSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.
Alan JamesSchool of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
Stefan KarraschInstitute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany; Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Beate KochDepartment of Internal Medicine B; Pneumology, Cardiology, Intensive Care Medicine; Field of Research: Pneumology and Pneumological Epidemiology, University Medicine Greifswald, Greifswald, Germany.
Stephen B KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Ashish KumarSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.
Lies LahousseDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Guo LiCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Kurt LohmanDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, New Zealand.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Bernd MeibohmCollege of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK and Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.
Alanna C MorrisonHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Bill MuskSchool of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
Kari E NorthGillings School of Global Public Health, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Lyle J PalmerOntario Institute for Cancer Research and Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada; Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.
Nicole M Probst-HenschSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Fernando RivadeneiraNetherlands Consortium for Healthy Aging, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Holger SchulzInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany and Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany.
Lewis J SmithNorthwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Akshay SoodUniversity of New Mexico, Albuquerque, New Mexico, United States of America.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom.
David P StrachanDivision of Population Health Sciences and Education, St George's, University of London, London, United Kingdom.
Alexander TeumerDepartment for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
André G UitterlindenNetherlands Consortium for Healthy Aging, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Henry VölzkeInstitute for Community Medicine, Study of Health In Pomerania (SHIP)/Clinical Epidemiological Research, University Medicine Greifswald, Greifswald, Germany.
Arend VoormanDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Louise V WainUniversity of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, United Kingdom; National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
Martin T WellsDepartment of Statistical Science, Cornell University, Ithaca, New York, United States of America.
Jemma B WilkThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
O Dale WilliamsFlorida International University, Miami, Florida, United States of America.
Susan R HeckbertCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Healthcare Inspectorate, The Hague, the Netherlands.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Martin D TobinUniversity of Leicester, Genetic Epidemiology Group, Department of Health Sciences, Leicester, United Kingdom; National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
George T O'ConnorThe National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; Section of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Ian P HallDivision of Respiratory Medicine, University Hospital of Nottingham, Nottingham, United Kingdom.
Patricia A CassanoDivision of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America; Department of Health Care Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, United States of America.
The University of Texas Health Science Center at Houston · USCornell University · USUniversitätsmedizin Greifswald · DEJohns Hopkins Medicine · USNetherlands Consortium for Healthy Ageing · NLSwiss Tropical and Public Health Institute · CHUniversity of Edinburgh · GBUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USWake Forest University · USBoston University · USErasmus MC · NLGerman Center for Lung Research · DEKaiser Permanente Washington Health Research Institute · USNational Institutes of Health · USThe University of Western Australia · AUUniversity of Liverpool · GBUppsala University · SEAlzheimer Scotland · GBBroad Institute · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
NUTRITION TRAININGT32DK007158 · NIDDK · CORNELL UNIVERSITY ITHACA · PI PATRICIA A CASSANO, Julia L. Finkelstein · 1986 to 2026
$7.4M
Genome-wide case-only study of antihypertensive drug-gene interactionsR01HL085251 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2010
$7.2M
Biotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/505Chief Scientist Office ETM/55Intramural NIH HHS Z01 ES043012Medical Research Council G0000934Medical Research Council G0700704Medical Research Council G0902313Medical Research Council G1000861Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01-HG-004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01-HG-004446NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01-HG-004729NHGRI NIH HHS U01 HG004738NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS HL085251NHLBI NIH HHS HL087652NHLBI NIH HHS HL103612NHLBI NIH HHS HL105756NHLBI NIH HHS N01 HC005187NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC045134NHLBI NIH HHS N01 HC045204NHLBI NIH HHS N01 HC045205NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01-HC-05187NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01-HC-45134NHLBI NIH HHS N01-HC-45204NHLBI NIH HHS N01-HC-45205NHLBI NIH HHS N01-HC-48047NHLBI NIH HHS N01-HC-48048NHLBI NIH HHS N01-HC-48049NHLBI NIH HHS N01-HC-48050NHLBI NIH HHS N01-HC-95095NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01-HL-084099NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS U01 HL080295NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG023629NIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062106NIA NIH HHS N01-AG-12100NIA NIH HHS N01AG2103,NIA NIH HHS N01AG62101,NIA NIH HHS N01AG62106,NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIA NIH HHS R01-AG028050NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIA NIH HHS RC1 AG035835NIA NIH HHS RC1AG035835.NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIDDK NIH HHS T32 DK007158NIDDK NIH HHS U01 DK062418NIEHS NIH HHS Z01 ES43012NINR NIH HHS R01 NR012459NINR NIH HHS R01-NR012459,PHS HHS HHSN268200625226CPHS HHS HHSN268200782096C.PHS HHS HHSN268200960009CWellcome Trust 068545/Z/02Wellcome Trust 076113/B/04/ZWellcome Trust 079895Wellcome Trust 086596/Z/08/ZWellcome Trust 090532Wellcome Trust 098017Wellcome Trust WT064890Wellcome Trust WT 084703MA
6 · The paper itself

Abstract

backgroundGenome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.

methodsWe performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.

resultsThe overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P  =  5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P  =  2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively.

conclusionsIn this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function.

Indexed as

Gene Expression RegulationGenetic LociGenome-Wide Association StudyAdultChromosomes, Human, Pair 11FemaleHumansLongitudinal StudiesMaleRespiration

Identifiers

PMID24983941
PMCPMC4077649
OpenAlexW2157186191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.