Evidence map›Paper›PMID 24983796›Full record

SynthesisJournal of anxiety disorders2014

The impact of symptom dimensions on outcome for exposure and ritual prevention therapy in obsessive-compulsive disorder.

Monnica T Williams, Samantha G Farris, Eric N Turkheimer, Martin E Franklin, H Blair Simpson, Michael Liebowitz, Edna B Foa

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Journal of anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 71 citations in OpenAlex.

  1. Trial
  2. Biomarkers of Obsessive-Compulsive Disorder Subtypes: A Literature Review.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. The prefrontal cortex and OCD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Distinguishing Fear Versus Distress Symptomatology in Pediatric OCD.Child psychiatry and human development · 2017
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Monnica T WilliamsUniversity of Pennsylvania, School of Medicine, Department of Psychiatry, 3535 Market Street, 6th Floor, Philadelphia, PA 19104, USA. Electronic address: m.williams@louisville.edu.
Samantha G FarrisUniversity of Pennsylvania, School of Medicine, Department of Psychiatry, 3535 Market Street, 6th Floor, Philadelphia, PA 19104, USA.
Eric N TurkheimerUniversity of Virginia, Department of Psychology, 102 Gilmer Hall, Box 400400, Charlottesville, VA 22904, USA.
Martin E FranklinUniversity of Pennsylvania, School of Medicine, Department of Psychiatry, 3535 Market Street, 6th Floor, Philadelphia, PA 19104, USA.
H Blair SimpsonColumbia University, Department of Psychiatry, Harkness Pavilion, 180 Ft. Washington Avenue, New York, NY 10032, USA; New York State Psychiatric Institute, Division of Clinical Therapeutics, 1051 Riverside Drive, Unit 69, New York, NY 10032, USA.
Michael LiebowitzColumbia University, Department of Psychiatry, Harkness Pavilion, 180 Ft. Washington Avenue, New York, NY 10032, USA.
Edna B FoaUniversity of Pennsylvania, School of Medicine, Department of Psychiatry, 3535 Market Street, 6th Floor, Philadelphia, PA 19104, USA.
University of Pennsylvania · USColumbia University · USNew York State Psychiatric InstituteUniversity of Virginia · US

Funding

Maximizing Treatment Outcome in OCDR01MH045404 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FOA, EDNA B · 1990 to 2016
$5.3M
Maximizing Treatment Outcome in OCDR01MH045436 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SIMPSON, HELEN BLAIR · 1990 to 2015
$5.0M
Enhancing Patient-Oriented Research and Training in OCDK24MH091555 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIMPSON, HELEN BLAIR · 2010 to 2014
$742k
NIMH NIH HHS K24 MH091555NIMH NIH HHS K24MH-MH091555NIMH NIH HHS R01 MH045404NIMH NIH HHS R01MH-045404-17S1NIMH NIH HHS R01 MH045436NIMH NIH HHS R01MH-45404NIMH NIH HHS R01MH-45436
6 · The paper itself

Abstract

objectiveObsessive-compulsive disorder (OCD) is a severe condition with varied symptom presentations. The behavioral treatment with the most empirical support is exposure and ritual prevention (EX/RP). This study examined the impact of symptom dimensions on EX/RP outcomes in OCD patients.

methodThe Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used to determine primary symptoms for each participant. An exploratory factor analysis (EFA) of 238 patients identified five dimensions: contamination/cleaning, doubts about harm/checking, hoarding, symmetry/ordering, and unacceptable/taboo thoughts (including religious/moral and somatic obsessions among others). A linear regression was conducted on those who had received EX/RP (n=87) to examine whether scores on the five symptom dimensions predicted post-treatment Y-BOCS scores, accounting for pre-treatment Y-BOCS scores.

resultsThe average reduction in Y-BOCS score was 43.0%, however the regression indicated that unacceptable/taboo thoughts (β=.27, p=.02) and hoarding dimensions (β=.23, p=.04) were associated with significantly poorer EX/RP treatment outcomes. Specifically, patients endorsing religious/moral obsessions, somatic concerns, and hoarding obsessions showed significantly smaller reductions in Y-BOCS severity scores.

conclusionsEX/RP was effective for all symptom dimensions, however it was less effective for unacceptable/taboo thoughts and hoarding than for other dimensions. Clinical implications and directions for research are discussed.

Indexed as

AdolescentAdultCeremonial BehaviorCognitive Behavioral TherapyCombined Modality TherapyFactor Analysis, StatisticalFemaleHoarding DisorderHumansImplosive TherapyMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesRandomized Controlled Trials as TopicSelective Serotonin Reuptake InhibitorsSelective Serotonin Reuptake InhibitorsExposure and response preventionFactor analysisHoardingObsessive-compulsive disorderSymptom dimensionsTreatment outcome

Identifiers

PMID24983796
PMCPMC4151097
OpenAlexW2110885332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.