ArticleMetabolites2014
NblA1/A2-Dependent Homeostasis of Amino Acid Pools during Nitrogen Starvation in Synechocystis sp. PCC 6803.
Article in Metabolites, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Physiological and molecular evidence for phycobilisome degradation in maintaining carbon and nitrogen balance of cyanobacteria.Marine life science & technology · 2025Article
- Limiting factors in the operation of photosystems I and II in cyanobacteria.Microbial biotechnology · 2024Review
- Identification of a c-type heme oxygenase and its function during acclimation of cyanobacteria to nitrogen fluctuations.Communications biology · 2023Article
- A Comparison of β-Carotene, Phytoene and Amino Acids Production inFoods (Basel, Switzerland) · 2021Article
- Effect of Light Intensity and Wavelength on Biomass Growth and Protein and Amino Acid Composition ofFoods (Basel, Switzerland) · 2021Article
- Phycobilisome breakdown effector NblD is required to maintain the cellular amino acid composition during nitrogen starvation.Journal of bacteriology · 2021Article
- CfrA, a Novel Carbon Flow Regulator, Adapts Carbon Metabolism to Nitrogen Deficiency in Cyanobacteria.Plant physiology · 2020Article
- Functional Differences in the Blooming Phytoplankton Heterosigma akashiwo and Prorocentrum donghaiense Revealed by Comparative Metaproteomics.Applied and environmental microbiology · 2019Article
- Population-level coordination of pigment response in individual cyanobacterial cells under altered nitrogen levels.Photosynthesis research · 2017Article
- Is RAF1 protein from Synechocystis sp. PCC 6803 really needed in the cyanobacterial Rubisco assembly process?Photosynthesis research · 2017Article
- Modification of photosynthetic electron transport and amino acid levels by overexpression of a circadian-related histidine kinase hik8 in Synechocystis sp. PCC 6803.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrient balance is important for photosynthetic growth and biomass production in microalgae. Here, we investigated and compared metabolic responses of amino acid pools to nitrogen and sulfur starvation in a unicellular model cyanobacterium, Synechocystis sp. PCC 6803, and its mutant nblA1/A2. It is known that NblA1/A2-dependent and -independent breakdown of abundant photosynthetic phycobiliproteins and other cellular proteins supply nutrients to the organism. However, the contribution of the NblA1/A2-dependent nutrient supply to amino acid pool homeostasis has not been studied. Our study demonstrates that changes in the pool size of many amino acids during nitrogen starvation can be categorized as NblA1/A2-dependent (Gln, Glu, glutathione, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Tyr and Val) and NblA1/A2-independent (Ala, Asn, Lys, and Trp). We also report unique changes in amino acid pool sizes during sulfur starvation in wild type and the mutant and found a generally marked increase in the Lys pool in cyanobacteria during nutrient starvation. In conclusion, the NblA1/A2-dependent protein turnover contributes to the maintenance of many amino acid pools during nitrogen starvation.
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Registered trials
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