Evidence map›Paper›PMID 24983704›Full record

ArticleCurrent opinion in microbiology2014

Deciphering nitric oxide stress in bacteria with quantitative modeling.

Jonathan L Robinson, Kristin J Adolfsen, Mark P Brynildsen

Abstract read
In one paragraph

Article in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
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  4. Proteome Profiling ofACS omega · 2022
    Article
  5. Article
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  7. Article
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  9. Article
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  12. TheFrontiers in microbiology · 2017
    Article
  13. Article
  14. Discovery and dissection of metabolic oscillations in the microaerobic nitric oxide response network of Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jonathan L RobinsonDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Kristin J AdolfsenDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Mark P BrynildsenDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address: mbrynild@princeton.edu.

Funding

Aminoglycoside-Enabled Elucidation of Persister MetabolismR21AI105342 · NIAID · PRINCETON UNIVERSITY · PI BRYNILDSEN, MARK P · 2013 to 2014
$417k
NIAID NIH HHS R21 AI105342NIAID NIH HHS R21AI105342
6 · The paper itself

Abstract

Many pathogens depend on nitric oxide (NO•) detoxification and repair to establish an infection, and inhibitors of these systems are under investigation as next-generation antibiotics. Because of the broad reactivity of NO• and its derivatives with biomolecules, a deep understanding of how pathogens sense and respond to NO•, as an integrated system, has been elusive. Quantitative kinetic modeling has been proposed as a method to enhance analysis and understanding of NO• stress at the systems-level. Here we review the motivation for, current state of, and future prospects of quantitative modeling of NO• stress in bacteria, and suggest that such mathematical approaches would prove equally useful in the study of other broadly reactive antimicrobials, such as hydrogen peroxide (H2O2).

Indexed as

Anti-Bacterial AgentsBacteriaHydrogen PeroxideNitric OxideOxidative StressReactive Oxygen SpeciesAnti-Bacterial AgentsHydrogen PeroxideNitric OxideReactive Oxygen Species

Identifiers

PMID24983704
PMCPMC4130159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.