ArticlePloS one2014
Novel high efficient coatings for anti-microbial surgical sutures using chlorhexidine in fatty acid slow-release carrier systems.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Antimicrobial-coated sutures to decrease surgical site infections: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Pooled it
- Trial
- Dual-Action Sutures: Chlorhexidine and Dexamethasone for Infection Control and Inflammation Suppression.Molecules (Basel, Switzerland) · 2026Article
- Antimicrobial Functionalization of Composite Nanofibrous Yarns as Surgical Sutures.Macromolecular bioscience · 2026Article
- Synthesis and characterization of clove/gelatin coated silk sutures for surgical site infection and wound healing.Journal of materials science. Materials in medicine · 2025Article
- PreventingACS applied bio materials · 2024Article
- Comparative Histopathological Evaluation of Gingival Tissue Reactions to Chlorhexidine-Coated and Uncoated Silk Sutures in Male Rats : Comparative Tissue Reactions to Chlorhexidine-Coated and Uncoated Silk Sutures.Galen medical journal · 2024Article
- Enhancing Dental Applications: A Novel Approach for Incorporating Bioactive Substances into Textile Threads.Pharmaceutics · 2023Article
- [Surgical suture material-fundamentals].Operative Orthopadie und Traumatologie · 2023Article
- Nanofiber-coated, tacrolimus-eluting sutures inhibit post-operative neointimal hyperplasia in rats.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- A review of current advancements for wound healing: Biomaterial applications and medical devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Review
- Prevention of Surgical Site Infections in Neonates and Children: Non-Pharmacological Measures of Prevention.Antibiotics (Basel, Switzerland) · 2022Article
- How Long Do Implanted Triclosan Sutures InhibitPharmaceutics · 2022Article
- Ultra-thin, high strength, antibiotic-eluting sutures for prevention of ophthalmic infection.Bioengineering & translational medicine · 2021Article
- In vitro evaluation of antibacterial efficacy of vancomycin-loaded suture tapes and cerclage wires.Journal of materials science. Materials in medicine · 2021Article
- Does skin preparation alter suture strength characteristics? Assessing the effect of chlorhexidine and isopropyl alcohol on common skin closure suture material.International wound journal · 2020Article
- Development of novel microenvironments for promoting enhanced wound healing.Current tissue microenvironment reports · 2020Article
- Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines.World journal of emergency surgery : WJES · 2020Review
- Contact Killing of Gram-Positive and Gram-Negative Bacteria on PDMS Provided with Immobilized Hyperbranched Antibacterial Coatings.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- The Antibiofilm Effect of a Medical Device Containing TIAB on Microorganisms Associated with Surgical Site Infection.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sutures can cause challenging surgical site infections, due to capillary effects resulting in bacteria permeating wounds. Anti-microbial sutures may avoid these complications by inhibiting bacterial pathogens. Recently, first triclosan-resistances were reported and therefore alternative substances are becoming clinically relevant. As triclosan alternative chlorhexidine, the "gold standard" in oral antiseptics was used. The aim of the study was to optimize novel slow release chlorhexidine coatings based on fatty acids in surgical sutures, to reach a high anti-microbial efficacy and simultaneously high biocompatibility. Sutures were coated with chlorhexidine laurate and chlorhexidine palmitate solutions leading to 11, 22 or 33 µg/cm drug concentration per length. Drug release profiles were determined in aqueous elutions. Antibacterial efficacy against Staphylococcus aureus was assessed in agar diffusion tests. Biocompatibility was evaluated via established cytotoxicity assay (WST-1). A commercially triclosan-containing suture (Vicryl Plus), was used as anti-microbial reference. All coated sutures fulfilled European Pharmacopoeia required tensile strength and proved continuous slow drug release over 96 hours without complete wash out of the coated drug. High anti-microbial efficacy for up to 5 days was observed. Regarding biocompatibility, sutures using 11 µg/cm drug content displayed acceptable cytotoxic levels according to ISO 10993-5. The highest potential for human application were shown by the 11 µg/cm chlorhexidine coated sutures with palmitic acid. These novel coated sutures might be alternatives to already established anti-microbial sutures such as Vicryl Plus in case of triclosan-resistance. Chlorhexidine is already an established oral antiseptic, safety and efficacy should be proven for clinical applications in anti-microbial sutures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.