Trial reportPloS one2014
Cardiac repolarization and autonomic regulation during short-term cold exposure in hypertensive men: an experimental study.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Responses to Cold Exposure in Hypertension
Year-round Health Enhancing Exercise and Coronary Artery Disease: Randomized Controlled Study
Who cites it
27 citing papers in PubMed.
- Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease.Scientific reports · 2021Trial
- Environmental conditions and cardiac autonomic function during an Antarctic summer expedition at James Ross Island.Scientific reports · 2026Article
- Causal relevance of the JAK/STAT pathway for cardioprotection via cold acclimation.Scientific reports · 2026Article
- Interpreting heart rate variability in clinical context: a framework for understanding a multidimensional autonomic biomarker.Frontiers in cardiovascular medicine · 2026Review
- Diagnostic accuracy of wearable ECG and assessment of ventricular repolarization and its cardiovascular risks post cold stress.Scientific reports · 2025Article
- Effect of PMScientific reports · 2025Article
- Short-term exposures to temperature and risk of sudden cardiac death in women: A case-crossover analysis in the Nurses' Health Study.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Association between baseline blood pressure variability and left heart function following short-term extreme cold exposure.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Impact of Ambient Temperature on Mortality Burden and Spatial Heterogeneity in 16 Prefecture-Level Cities of a Low-Latitude Plateau Area in Yunnan Province: Time-Series Study.JMIR public health and surveillance · 2024Article
- Burden of Stroke Attributable to Nonoptimal Temperature in 204 Countries and Territories: A Population-Based Study, 1990-2019.Neurology · 2024Article
- Association of cause-specific hospital admissions with high and low temperatures in Thailand: a nationwide time series study.The Lancet regional health. Western Pacific · 2024Article
- Effects of Daily Mean Temperature on Daily Hospital Admissions for Coronary Artery Disease: A Retrospective Study.Risk management and healthcare policy · 2024Article
- Electrocardiography Assessment of Sympatico-Vagal Balance during Resting and Pain Using the Texas Instruments ADS1299.Bioengineering (Basel, Switzerland) · 2023Article
- Ceftazidime/Avibactam, Polymyxin or Tigecycline as a Rescue Strategy for the Treatment of Carbapenem-ResistantInfection and drug resistance · 2023Article
- Low temperature and temperature decline increase acute aortic dissection risk and burden: A nationwide case crossover analysis at hourly level among 40,270 patients.The Lancet regional health. Western Pacific · 2022Article
- Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults.Physiological reports · 2021Article
- Heart Rate Variability (HRV) and Pulse Rate Variability (PRV) for the Assessment of Autonomic Responses.Frontiers in physiology · 2020Article
- Association between ambient temperature and mortality risk and burden: time series study in 272 main Chinese cities.BMJ (Clinical research ed.) · 2018Article
- Cardiovascular diseases, cold exposure and exercise.Temperature (Austin, Tex.) · 2018Review
- Sympathetic function during whole body cooling is altered in hypertensive adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of our study was to assess the effect of short-term cold exposure, typical in subarctic climate, on cardiac electrical function among untreated middle-aged hypertensive men.
methodsWe conducted a population-based recruitment of 51 hypertensive men and a control group of 32 men without hypertension (age 55-65 years) who underwent whole-body cold exposure (15 min exposure to temperature -10°C, wind 3 m/s, winter clothes). Conduction times and amplitudes, vectorcardiography, arrhythmias, and heart rate variability (autonomic nervous function) were assessed.
resultsShort-term cold exposure increased T-peak to T-end interval from 67 to 72 ms (p<0.001) and 71 to 75 ms (p<0.001) and T-wave amplitude from 0.12 to 0.14 mV (p<0.001) and from 0.17 to 0.21 mV (p<0.001), while QTc interval was shortened from 408 to 398 ms (p<0.001) and from 410 to 401 ms (p<0.001) among hypertensive men and controls, respectively. Cold exposure increased both low (from 390 to 630 ms2 (p<0.001) and 380 to 700 ms2 (p<0.001), respectively) and high frequency heart rate variability (from 90 to 190 ms2 (p<0.001) and 150 to 300 ms2 (p<0.001), respectively), while low-to-high frequency-ratio was reduced. In addition, the frequency of ventricular ectopic beats increased slightly during cold exposure. The cold induced changes were similar between untreated hypertensive men and controls.
conclusionsShort-term cold exposure with moderate facial and mild whole body cooling resulted in prolongation of T-peak to T-end interval and higher T-wave amplitude while QTc interval was shortened. These changes of ventricular repolarization may have resulted from altered cardiac autonomic regulation and were unaffected by untreated hypertension.
trial registrationClinicalTrials.gov NCT02007031.
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