ArticlePloS one2014
Novel host-related virulence factors are encoded by squirrelpox virus, the main causative agent of epidemic disease in red squirrels in the UK.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- The role of red squirrels in leprosy dynamics in the United Kingdom: a critical review.One health (Amsterdam, Netherlands) · 2025Article
- 20 years of research on giant viruses.Npj viruses · 2025Review
- The Many Faces of Oligoadenylate Synthetases.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023Review
- Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses.FEMS microbiology reviews · 2023Article
- Health Status of the Eastern Grey Squirrel (Animals : an open access journal from MDPI · 2022Article
- A Peek into the Bacterial Microbiome of the Eurasian Red Squirrel (Animals : an open access journal from MDPI · 2022Article
- Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation.Molecular biology and evolution · 2021Article
- Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.PLoS biology · 2020Article
- The genome sequence of the Eurasian red squirrel,Wellcome open research · 2020Article
- The genome sequence of the eastern grey squirrel,Wellcome open research · 2020Article
- cGAS and CD-NTase enzymes: structure, mechanism, and evolution.Current opinion in structural biology · 2019Review
- Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses.Journal of virology · 2019Article
- Molecular and microscopic characterization of a novel Eastern grey kangaroopox virus genome directly from a clinical sample.Scientific reports · 2017Article
- Berlin Squirrelpox Virus, a New Poxvirus in Red Squirrels, Berlin, Germany.Emerging infectious diseases · 2017Article
- Article
- Genome variability and gene content in chordopoxviruses: dependence on microsatellites.Viruses · 2015Article
- Pathogens as biological weapons of invasive species.PLoS pathogens · 2015Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squirrelpox virus (SQPV) shows little evidence for morbidity or mortality in North American grey squirrels (Sciurus carolinensis), in which the virus is endemic. However, more recently the virus has emerged to cause epidemics with high mortality in Eurasian red squirrels (S. vulgaris) in Great Britain, which are now threatened. Here we report the genome sequence of SQPV. Comparison with other Poxviridae revealed a core set of poxvirus genes, the phylogeny of which showed SQPV to be in a new Chordopoxvirus subfamily between the Molluscipoxviruses and Parapoxviruses. A number of SQPV genes were related to virulence, including three major histocomaptibility class I homologs, and one CD47 homolog. In addition, a novel potential virulence factor showing homology to mammalian oligoadenylate synthetase (OAS) was identified. This family of proteins normally causes activation of an endoribonuclease (RNaseL) within infected cells. The putative function of this novel SQPV protein was predicted in silico.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.