ArticleMedicine and science in sports and exercise2015
ASIC3 contributes to the blunted muscle metaboreflex in heart failure.
Article in Medicine and science in sports and exercise, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Insulin potentiates mechanical responses in small dorsal root ganglion neurons by increasing the sensitization of TRPV4 channels.American journal of physiology. Cell physiology · 2025Article
- Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure.Experimental physiology · 2025Review
- Cardiovascular responses to static handgrip exercise and postexercise ischemia in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents.The Journal of physiology · 2023Article
- Hemodynamic responses to handgrip and metaboreflex activation are exaggerated in individuals with metabolic syndrome independent of resting blood pressure, waist circumference, and fasting blood glucose.Frontiers in physiology · 2023Article
- Novel mechanosensory role for acid sensing ion channel subtype 1a in evoking the exercise pressor reflex in rats with heart failure.The Journal of physiology · 2022Article
- Metabo- and mechanoreceptor expression in human heart failure: Relationships with the locomotor muscle afferent influence on exercise responses.Experimental physiology · 2020Article
- Enhanced maximal exercise capacity, vasodilation to electrical muscle contraction, and hind limb vascular density in ASIC1a null mice.Physiological reports · 2017Article
- Heart failure induces changes in acid-sensing ion channels in sensory neurons innervating skeletal muscle.The Journal of physiology · 2015Article
- ASICs and cardiovascular homeostasis.Neuropharmacology · 2015Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionDuring exercise, the sympathetic nervous system is activated and blood pressure and HR increase. In heart failure (HF), the muscle metaboreceptor contribution to sympathetic outflow is attenuated and the mechanoreceptor contribution is accentuated. Previous studies suggest that lactic acid stimulates acid-sensing channel subtype 3 (ASIC3), inducing a neurally mediated pressor response. Thus, we hypothesized that the pressor response to ASIC3 stimulation is smaller in HF rats because of attenuation in expression and function of ASIC3 in sensory nerves.
methodsLactic acid was injected into the arterial blood supply of the hind limb to stimulate ASIC3 in muscle afferent nerves and evoke muscle metaboreceptor response in control rats and HF rats. In addition, western blot analysis was used to examine expression of ASIC3 in dorsal root ganglion (DRG) and patch clamp to examine current response with ASIC3 activation.
resultsLactic acid (4 μmol·kg) increased mean arterial pressure by 28 ± 5 mm Hg in controls (n = 6) but only by 16 ± 3 mm Hg (P < 0.05 vs control) in HF (n = 8). In addition, HF decreased the protein levels of ASIC3 in DRG (optical density, 1.03 ± 0.02 in control, vs 0.79 ± 0.03 in HF; P < 0.05; n = 6 in each group). The peak current amplitude of dorsal DRG neuron in response to ASIC3 stimulation is smaller in HF rats than that in control rats.
conclusionsCompared with those in controls, cardiovascular responses to lactic acid administered into the hind limb muscles are blunted in HF rats owing to attenuated ASIC3. This suggests that ASIC3 plays a role in engagement in the attenuated metaboreceptor component of the exercise pressor reflex in HF.
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