Trial reportNeurosciences (Riyadh, Saudi Arabia)2014
Early versus late surgical decompression for traumatic thoracic/thoracolumbar (T1-L1) spinal cord injured patients. Primary results of a randomized controlled trial at one year follow-up.
Trial report in Neurosciences (Riyadh, Saudi Arabia), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The time-dependent efficacy of early surgical decompression in patients with traumatic spinal cord injury: A systematic review and meta-analysis.The journal of spinal cord medicine · 2026Pooled it
- Association between surgical timing and neurological recovery after traumatic spinal cord injury.European journal of medical research · 2025Pooled it
- Review
- Early versus Delayed Surgical Decompression in Spinal Cord Injury: A Systematic Review and Meta-Analysis.Asian journal of neurosurgery · 2025Review
- Time is spine: critical updates for the intensivist.Current opinion in critical care · 2025Review
- An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery.Global spine journal · 2024Article
- Timing of Decompressive Surgery in Patients With Acute Spinal Cord Injury: Systematic Review Update.Global spine journal · 2024Article
- Under pressure - A historical vignette on surgical timing in traumatic spinal cord injury.Brain & spine · 2024Review
- Care needs of adults with spinal trauma in the prehospital and hospital setting from the perspective of patient care team: A qualitative research.Journal of education and health promotion · 2024Article
- Adopting and adapting clinical practice guidelines for timing of decompressive surgery in acute spinal cord injury from a developed world context to a developing region.Acta neurochirurgica · 2023Review
- Time is spine: What's over the horizon.Journal of clinical orthopaedics and trauma · 2022Article
- Early versus Delayed Surgery for Acute Traumatic Cervical/Thoracic Spinal Cord Injury in Beijing, China: The Results of a Prospective, Multicenter Nonrandomized Controlled Trial.Orthopaedic surgery · 2021Article
- Variability in time to surgery for patients with acute thoracolumbar spinal cord injuries.Scientific reports · 2021Article
- Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats.Stem cell research & therapy · 2021Article
- Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature.Frontiers in surgery · 2021Review
- Timing of Surgery in Thoracolumbar Spine Injury: Impact on Neurological Outcome.Global spine journal · 2020Article
- Complete Traumatic Spinal Cord Injury: Current Insights Regarding Timing of Surgery and Level of Injury.Global spine journal · 2020Article
- A Randomized Controlled Trial of Early versus Late Surgical Decompression for Thoracic and Thoracolumbar Spinal Cord Injury in 73 Patients.Neurotrauma reports · 2020Article
- Early Surgery for Traumatic Spinal Cord Injury: Where Are We Now?Global spine journal · 2020Article
- Timing of Decompression in Patients With Acute Spinal Cord Injury: A Systematic Review.Global spine journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the efficacy of surgical decompression <24 (early) versus 24-72 hours (late) in thoracic/thoracolumbar traumatic spinal cord injury (TSCI).
methodsA randomized controlled trial (RCT) of 35 T1-L1 TSCI patients including early (n=16) and late (n=19) surgical decompression was conducted in the neurosurgery department of Shahid Rajaee Hospital from September 2010. Pre- and postoperative American Spinal Injury Association (ASIA) Impairment Scale (AIS), ASIA motor/sensory scores, length of hospitalization, complications, postoperative vertebral height restoration/rebuilding and angle reduction, and 12-month loss of height restoration/rebuilding and angle reduction were evaluated.
resultsSixteen patients (46%) had complete TSCI. No AIS change was seen in 17 (52%) patients. Complete TSCI patients had no motor improvement. The AIS change in this group was solely due to increased sensory scores. For incomplete TSCI, the mean motor score improved from 77 (± 22) to 92 (± 12) in early, and from 68 (± 22) to 82 (± 16) in late surgery. One deep vein thrombosis was observed in each group. There were 2 wound infections, one CSF leak, one case of meningitis, and one decubitus ulcer in the late surgery group. Six screw revisions were required.
conclusionOur primary results show overall AIS and motor score improvement in both groups. Motor improvement was only observed in incomplete TSCI. Two-grade improvements in AIS were seen in 3 early, and one late surgery patient.
Indexed as
Identifiers
24983279PMC4727651What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.