ArticleBioMed research international2014
Identification, typing, antifungal resistance profile, and biofilm formation of Candida albicans isolates from Lebanese hospital patients.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Antifungal Use and Resistance in a Lower-Middle-Income Country: The Case of Lebanon.Antibiotics (Basel, Switzerland) · 2023Article
- Characterization and susceptibility of non-albicansFrontiers in public health · 2023Observational
- Prevalence and Antifungal Susceptibility of Clinically RelevantTropical medicine and infectious disease · 2022Article
- Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinicalSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- The immunomodulatory effects of Candida albicans isolated from the normal gastrointestinal microbiome of the elderly on colorectal cancer.Medical oncology (Northwood, London, England) · 2021Article
- Whole genome sequencing of a clinical drug resistantJournal of medical microbiology · 2021Article
- Evaluation of Microsatellite Typing, ITS Sequencing, AFLP Fingerprinting, MALDI-TOF MS, and Fourier-Transform Infrared Spectroscopy Analysis ofJournal of fungi (Basel, Switzerland) · 2020Article
- Assessment of antifungal resistance and associated molecular mechanism in Candida albicans isolates from different cohorts of patients in North Indian state of Haryana.Folia microbiologica · 2020Article
- Cutaneous candidiasis in Tehran-Iran: from epidemiology to multilocus sequence types, virulence factors and antifungal susceptibility of etiologicIranian journal of microbiology · 2019Article
- Microevolution of the pathogenic yeastsMicrobial cell (Graz, Austria) · 2019Review
- Relationship between Sap prevalence and biofilm formation among resistant clinical isolates ofAfrican health sciences · 2018Article
- Hexane extract from Spondias tuberosa (Anacardiaceae) leaves has antioxidant activity and is an anti-Candida agent by causing mitochondrial and lysosomal damages.BMC complementary and alternative medicine · 2018Article
- Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All.Journal of fungi (Basel, Switzerland) · 2018Review
- Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit.Advances in medicine · 2016Article
- Comparison of various methods used to detect biofilm production of Candida species.Journal of clinical and diagnostic research : JCDR · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As leading opportunistic fungal pathogens identification and subtyping of Candida species are crucial in recognizing outbreaks of infection, recognizing particularly virulent strains, and detecting the emergence of drug resistant strains. In this study our objective was to compare identification of Candida albicans by the hospitals through the use of conventional versus identification based on the ITS (Internal Transcribed Spacer) and to assess biofilm forming capabilities, drug resistance patterns and correlate these with MLST typing. ITS typing revealed a 21.2% hospital misidentification rate. Multidrug resistance to three drugs out of four tested was detected within 25% of the isolates raising concerns about the followed treatment regimens. Drug resistant strains as well as biofilm formers were phylogenetically related, with some isolates with significant biofilm forming capabilities being correlated to those that were multidrug resistant. Such isolates were grouped closely together in a neighbor-joining tree generated by MLST typing indicating phylogenetic relatedness, microevolution, or recurrent infection. In conclusion, this pilot study gives much needed insight concerning C. albicans isolates circulating in Lebanese hospitals and is the first study of its kind correlating biofilm formation, antifungal resistance, and evolutionary relatedness.
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