ArticleBioMed research international2014
Development and maturation of the immune system in preterm neonates: results from a whole genome expression study.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass.CPT: pharmacometrics & systems pharmacology · 2019Trial
- The immune system of preterm infants: an overview.Frontiers in immunology · 2026Review
- Association between maternal preeclampsia and the risk of neonatal sepsis: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper.Respiratory research · 2023Article
- The Lactoferrin Phenomenon-A Miracle Molecule.Molecules (Basel, Switzerland) · 2022Review
- Antibodies targetingFrontiers in immunology · 2022Article
- Potential role of IFN-γ and IL-5 in sepsis prediction of preterm neonates.Open medicine (Warsaw, Poland) · 2021Article
- Executive Dysfunction Early Postnatal Biomarkers among Children Born Extremely Preterm.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Chorioamnionitis exposure remodels the unique histone modification landscape of neonatal monocytes and alters the expression of immune pathway genes.The FEBS journal · 2019Article
- Socioeconomic status and early blood concentrations of inflammation-related and neurotrophic proteins among extremely preterm newborns.PloS one · 2019Observational
- Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Article
- Effect of HTST and Holder Pasteurization on the Concentration of Immunoglobulins, Growth Factors, and Hormones in Donor Human Milk.Frontiers in immunology · 2018Article
- Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Observational
- Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis.Mediators of inflammation · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To expand the knowledge about the consecutive expression of genes involved in the immune system development in preterm neonates and to verify if the environment changes the gene expression after birth we conducted a prospective study that included three cohorts: (A) extremely (gestational age (GA): 23-26 weeks; n = 41), (B) very (GA: 27-29 weeks; n = 39), and (C) moderately preterm infants (GA: 30-32 weeks; n = 33). Blood samples were drawn from the study participants on the 5th and 28th day of life (DOL). The mRNA samples were evaluated for gene expression with the use of GeneChip Human Gene 1.0ST microarrays. Differential expression analysis revealed small subsets of genes that presented positive or negative monotone trends in both the 5th (138 genes) and 28th DOL (308 genes) in the three subgroups of patients. Based on pathway enrichment analysis, we found that most of the pathways that revealed a positive monotone trend were involved in host immunity. The most significantly GA dependent pathways were T-cell receptor signaling pathway and intestinal immune network for IgA production. Overall 4431 genes were differentially expressed between the 5th and 28th DOL. Despite differences in gestational age, patients with the same postconceptional age have a very similar expression of genes.
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