Evidence map›Paper›PMID 24982877›Full record

ArticleBioMed research international2014

Polymorphisms of β 1-adrenoreceptor gene and cardiovascular complications in patients with thyrotoxicosis.

A Y Babenko, E N Grineva, D A Savitskaja, E N Kravchuk, V N Solncev, A A Kostareva

Open access · hybridAbstract read
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Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

A Y BabenkoAlmazov Federal Medical Research Centre, Institute of Endocrinology, Saint Petersburg, Russia.
E N GrinevaAlmazov Federal Medical Research Centre, Institute of Endocrinology, Saint Petersburg, Russia.
D A SavitskajaAlmazov Federal Medical Research Centre, Institute of Endocrinology, Saint Petersburg, Russia.
E N KravchukAlmazov Federal Medical Research Centre, Institute of Endocrinology, Saint Petersburg, Russia.
V N SolncevAlmazov Federal Medical Research Centre, Group of Medical Statistic, Saint Petersburg, Russia.
A A KostarevaAlmazov Federal Medical Research Centre, Institute of Molecular Biology and Genetics, Saint Petersburg, Russia.
Federal Almazov North-West Medical Research Centre · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cardiac β 1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β 1-adrenoreceptors ( β 1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied. We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.

Indexed as

Genetic Predisposition to DiseaseAdultAmino Acid SubstitutionAtrial FibrillationCardiovascular DiseasesCase-Control StudiesFemaleGene FrequencyGraves DiseaseHumansMalePolymorphism, Single NucleotideReceptors, Adrenergic, beta-1ThyrotoxicosisUltrasonographyReceptors, Adrenergic, beta-1

Identifiers

PMID24982877
PMCPMC4055531
OpenAlexW2031274800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.