ReviewAnnals of laboratory medicine2014
Update on procalcitonin measurements.
Review in Annals of laboratory medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07696897 (Comparative Diagnostic Accuracy of Procalcitonin Versus Serum Zinc as Biomarkers for the Diagnosis of Ventilator Acquired Pneumonia in Adults Admitted to the ICU), which is not on this map. Cited by 175 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Diagnostic Accuracy of Procalcitonin Versus Serum Zinc as Biomarkers for the Diagnosis of Ventilator Acquired Pneumonia in Adults Admitted to the ICU
Who cites it
175 citing papers in PubMed, 8 syntheses or guidelines pooled it, 374 citations in OpenAlex.
- Is procalcitonin superior to CRP and ESR in the diagnosis of diabetic foot osteomyelitis? A systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Inflammatory blood parameters as prognostic factors for implant-associated infection after primary total hip or knee arthroplasty: a systematic review.BMC musculoskeletal disorders · 2023Pooled it
- Procalcitonin as a Candidate Biomarker for Malarial Infection and Severe Malaria: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Pooled it
- Procalcitonin as a predictive marker in COVID-19: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2020Pooled it
- Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Comparison of Four Days Versus Seven Days Duration of Antibiotic Therapy for Neonatal Pneumonia: A Randomized Controlled Trial.Indian journal of pediatrics · 2018Trial
- Optimal Timing of Serum Lipase for Early Prediction of Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy.Cancers · 2026Article
- Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay.Diagnostics (Basel, Switzerland) · 2026Article
- Procalcitonin kinetics in critically ill patients: a retrospective analysis of the impact of renal dysfunction and renal replacement therapy.Journal of anesthesia, analgesia and critical care · 2026Article
- Lactate/albumin ratio as an independent predictor of mortality in pediatric trauma patients admitted to a pediatric intensive care unit.European journal of pediatrics · 2026Article
- [Abnormally Elevated Procalcitonin in Stage IV Lung Adenocarcinoma with Neuroendocrine Differentiation: A Case Report and Literature Review].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- Variation of Procalcitonin Level in Elective Cardiac Surgery at a Tertiary Cardiac Centre: A Prospective Longitudinal Study.Health science reports · 2026Article
- A retrospective analysis of risk factors for intestinal necrosis in pediatric secondary intussusception.BMC pediatrics · 2026Article
- Procalcitonin Elevation in Intoxication- and Immobilization-Related Non-Traumatic Rhabdomyolysis: Association with Muscle Injury Severity and Renal Dysfunction.Biomedicines · 2026Article
- Serum Procalcitonin to Support Early Triage for Possible Systemic Infection in Patients with Endophthalmitis.Diagnostics (Basel, Switzerland) · 2026Article
- Dynamics of Inflammatory Parameters in Hospitalized and Surgically Treated Patients with Odontogenic Abscesses.Medicina (Kaunas, Lithuania) · 2026Article
- Thyroid Storm With Multiorgan Dysfunction Mimicking Sepsis: Thionamide-Sparing Bridge to Delayed Carbimazole.Cureus · 2026Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Procalcitonin (PCT) is used as a biomarker for the diagnosis of sepsis, severe sepsis and septic shock. At the same time, PCT has also been used to guide antibiotic therapy. This review outlines the main indications for PCT measurement and points out possible pitfalls. The classic indications for PCT measurement are: (i) confirmation or exclusion of diagnosis of sepsis, severe sepsis, or septic shock, (ii) severity assessment and follow up of systemic inflammation mainly induced by microbial infection, and (iii) individual, patient adapted guide of antibiotic therapy and focus treatment. Using serially monitored PCT levels, the duration and need of antibiotic therapy can be better adapted to the individual requirements of the patient. This individualized approach has been evaluated in various studies, and it is recommended to be a part of an antibiotic stewardship program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.