ArticleCentral European journal of urology2014
Effectiveness of combined high-dosed trospium and solifenacin depending on severity of OAB symptoms in elderly men and women under cyclic therapy.
Article in Central European journal of urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Combination and Novel Pharmacologic Agents for OAB.Current urology reports · 2022Review
- Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction.Chinese journal of integrative medicine · 2018Article
- A new tool for self-evaluation of adherence to antimuscarinic drugs treatment in patients with urinary incontinence.Arab journal of urology · 2017Article
- Comparison of objective and subjective factors in the adherence to antimuscarinics when treating overactive bladder in employed persons.Therapeutic advances in urology · 2017Article
- Self-assessment of treatment compliance with antimuscarinic drugs and lower urinary tract condition among women with urinary incontinence.International urogynecology journal · 2017Article
- Long-term adherence to antimuscarinic drugs when treating overactive bladder in the older: Subjective reason and objective factors.Investigative and clinical urology · 2017Article
- Social, Economic, and Medical Factors Associated With Solifenacin Therapy Compliance Among Workers Who Suffer From Lower Urinary Tract Symptoms.International neurourology journal · 2016Article
- Refractory overactive bladder: a common problem?International urogynecology journal · 2015Review
- The efficacy of different doses of solifenacin in elderly patients after treating a urinary tract infection.Arab journal of urology · 2015Article
- A novel approach to overactive bladder syndrome treatment.Central European journal of urology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MATERIAL AND
methods313 patients, 196 women and 117 men over 65 (average age 68.6) were included in this study. All patients underwent urodynamic examination before enrollment and after the study was completed. For clinical evaluation of LUT state ICIQ-SF questionnaires and bladder diaries were used. Patients with moderate (А, n = 155) and severe (В, n = 158) symptoms of OAB. Each group was divided into subgroups in which patients received Trospium 60 mg/day and Solifenacin 20 mg/day during two cycles - 1.5 and 1 month with one month interval (А1 and В1); subgroups in which second cycle was substituted with placebo (А2, В2), and control groups (А3, В3).
resultsIn groups with moderate symptoms of OAB ratio of patients demonstrated decrease of frequency of EI ≥1.5 a day remained at the level of 45-60% during all observation period. In subgroups with severe symptoms of OAB percentage of such patients was 55.3% for the subgroup which received two cycle therapy, and decreased to 26% in the subgroup which underwent 1 cycle therapy. Urodynamic indices for state of LUT correlated with clinical indicators (r =0.57-0.71 at p≤ 0.05).
conclusionsShort single cycle of high-dosed Solifenacin and Trospium in elderly patients with moderate symptoms of OAB enables to maintain long therapeutic effect with acceptable level of side effects. This treatment algorithm applied in two cycle course is an effective and safe method for management of severe symptoms of OAB in elderly patients without increased risk of side effects.
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