ArticleFrontiers in behavioral neuroscience2014
Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
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- Resveratrol Neuroprotective Action Against Cognitive Impairments Induced by Lorazepam in Male Rats.Current drug safety · 2025Article
- Early life exposure to clonazepam has both short- and long-term effects on seizures induced with pentylenetetrazol (PTZ).Frontiers in pharmacology · 2025Article
- Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague.Physiological research · 2024Review
- The outcome of early life status epilepticus-lessons from laboratory animals.Epilepsia open · 2023Article
- The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats.Pharmaceutics · 2021Article
- Neonatal administration of a subanaesthetic dose of JM-1232(-) in mice results in no behavioural deficits in adulthood.Scientific reports · 2021Article
- Valproic acid treated female Long-Evans rats are impaired on attentional set-shifting.Behavioural brain research · 2021Article
- Neonatal Clonazepam Administration Induced Long-Lasting Changes in GABAInternational journal of molecular sciences · 2020Article
- Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors.Frontiers in molecular neuroscience · 2018Article
- Article
- Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.Epilepsy & behavior : E&B · 2016Article
- Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome.Translational psychiatry · 2016Article
- Cognitive deficits in schizophrenia and other neuropsychiatric disorders: convergence of preclinical and clinical evidence.Frontiers in behavioral neuroscience · 2014Article
- Mitochondrial Toxicity by 3-NP Enhanced Susceptibility to Defective Social Behaviors in Male Wistar Rats.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social behavior represents an integral part of behavioral repertoire of rats particularly sensitive to pharmacological and environmental influences. The aim of the present study was to investigate whether early postnatal clonazepam (CZP) exposure can induce age-dependent changes related to expression of social behavior. The drug was administered from postnatal day (P) 7 until P11 at daily doses of 0.1, 0.5 and 1.0 mg/kg i.p. We designed three experiments to assess whether exposure to CZP affects social behavior in respect to the age of rats and the test circumstances, specifically their familiarity with test conditions during adolescence (P32), social behavior in juveniles and adolescents (P18-P42) and social behavior in a resident-intruder paradigm. The frequency and duration of a various patterns of social behavior related to play and social investigation not related to play were evaluated. The results showed that CZP postnatal exposure decreased social play behavior regardless of age and familiarity or unfamiliarity of experimental environment but did not affect the social investigation per se. When rats were confronted with an intruder in their home cages intense wrestling and inhibition of genital investigation were found. In conclusion, these findings show that short-term CZP postnatal exposure inhibits social play behavior and alters specific patterns of social behavior in an age and environment related manner.
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