Evidence map›Paper›PMID 24982333›Full record

ArticleAnticancer research2014

Differential growth inhibition of cerebral metastases by anti-angiogenic compounds.

Daniel K Martin, Ortrud Uckermann, Aiko Bertram, Corina Liebner, Sandy Hendruschk, Kerim Hakan Sitoci-Ficici, Gabriele Schackert, Edith M Lord, Achim Temme, Matthias Kirsch

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Anticancer research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Daniel K MartinDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Ortrud UckermannDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Aiko BertramDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Corina LiebnerDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Sandy HendruschkDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Kerim Hakan Sitoci-FiciciDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Gabriele SchackertDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Edith M LordDepartment of Microbiology and Immunology, James P. Wilmot Cancer Center, University of Rochester, Rochester, NY, U.S.A.
Achim TemmeDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany CRTD/DFG-Center for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany.
Matthias KirschDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany CRTD/DFG-Center for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany matthias.kirsch@uniklinikum-dresden.de.
University Hospital Carl Gustav Carus · DE

Funding

IN SITU ANTITUMOR IMMUNITY AND EFFECTS OF RADIATIONR01CA028332 · NCI · UNIVERSITY OF ROCHESTER · PI LORD, EDITH M · 1985 to 2020
$5.0M
NCI NIH HHS R01 CA028332
6 · The paper itself

Abstract

backgroundThe formation of brain metastases is intrinsically linked to concomitant angiogenesis. The purpose of the present study was to investigate the combined effects of interleukin-12 (IL-12) and EMD121974 on the growth and distribution of melanoma brain metastases since both substances may interact with important steps in the cascade of brain metastases formation. MATERIALS AND

methodsBrain metastases were induced by either stereotactic implantation of cells to the brain parenchyma or by injection of the melanoma cells into the internal carotid artery to mimic hematogenous metastatic spread in mice. Naive or IL-12-overexpressing murine K1735 melanoma cells were used either alone or in combination with intraperitoneal anti-integrin treatment using EMD121974.

resultsSolid melanoma metastases were more susceptible to daily low-dose treatment of EMD121974 than multiple hematogenous metastases. Interleukin-12 had a profound effect on both types of brain metastases. After 21 days, a marked reduction of vascularity was observed in both tumor types.

conclusionThe combination of endogenous IL-12 production with integrin blockade resulted in additive effects for murine hematogenous brain metastases but not for focal brain metastases.

Indexed as

Angiogenesis InhibitorsAnimalsApoptosisBrain NeoplasmsCell Growth ProcessesCell Line, TumorCombined Modality TherapyFemaleGenetic TherapyInterleukin-12MelanomaMiceMice, NudePeptides, CyclicSnake VenomsTransfectionAngiogenesis InhibitorsCilengitideInterleukin-12Peptides, CyclicSnake VenomsBrain metastasesbrain tumorcilengitideEMD121974interleukin-12melanoma

Identifiers

PMID24982333
PMCPMC4388740
OpenAlexW2308026362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.