Evidence map›Paper›PMID 24982332›Full record

ArticleAnticancer research2014

Coordinated expression of cyclin-dependent kinase-4 and its regulators in human oral tumors.

Ming J Poi, Thomas J Knobloch, Marta T Sears, Lana K Uhrig, Blake M Warner, Christopher M Weghorst, Junan Li

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Anticancer research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ming J PoiDepartment of Pharmacy, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, U.S.A Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
Thomas J KnoblochDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
Marta T SearsDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A.
Lana K UhrigDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A.
Blake M WarnerDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A College of Dentistry, The Ohio State University, Columbus, OH, U.S.A.
Christopher M WeghorstDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, U.S.A.
Junan LiDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A li.225@osu.edu.
Ohio Department of Health · USThe Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe Ohio State University Wexner Medical Center · US

Funding

Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
NIDCR NIH HHS T32 DE014320
6 · The paper itself

Abstract

BACKGROUND/

aimWhile aberrant expression of cyclin-dependent kinase-4 (CDK4) has been found in squamous cell carcinoma of the head and neck (SCCHN), the associations between CDK4 and its regulators, namely, cyclin D1, cyclin E, gankyrin, SEI1, and BMI1 in gene expression remain to be explored. Herein we investigated the mRNA profiles of these oncogenes and their interrelations in different oral lesion tissues. MATERIALS AND

methodsThirty SCCHN specimens and patient-matched high at-risk mucosa (HARM) and 16 healthy control specimens were subjected to quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses.

resultsThe mRNA levels of CDK4, cyclin D1, gankyrin, SEI1, BMI1 were significantly elevated in both HARM and SCCHN (in comparison with control specimens), and statistically significant correlations were found among these markers in gene expression.

conclusionUp-regulation of CDK4 and its regulators takes place in oral cancer progression in a coordinate manner, and HARM and SCCHN share a similar molecular signature within the CDK4-pRB pathway.

Indexed as

AdultCarcinoma, Squamous CellCase-Control StudiesCyclin D1Cyclin-Dependent Kinase 4Cyclin EFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedMitogen-Activated Protein Kinase 7Mouth NeoplasmsNuclear ProteinsPrincipal Component AnalysisProteasome Endopeptidase ComplexCCND1 protein, humanCDK4 protein, humanCyclin D1Cyclin-Dependent Kinase 4Cyclin EMAPK7 protein, humanMitogen-Activated Protein Kinase 7Nuclear ProteinsProteasome Endopeptidase ComplexProto-Oncogene ProteinsPSMD10 protein, humanRNA, MessengerSERTAD1 protein, humanTrans-ActivatorsTranscription FactorscoordinationCyclin-dependent kinase 4squamous cell carcinoma of the head and necktranscription up-regulation

Identifiers

PMID24982332
PMCPMC4183149
OpenAlexW1920484186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.