ArticleJournal of the American Dental Association (1939)2014
Dental sealants and restorations and urinary bisphenol A concentrations in children in the 2003-2004 National Health and Nutrition Examination Survey.
Article in Journal of the American Dental Association (1939), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?-A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Bisphenol A in contemporary dentistry: from material chemistry and exposure pathways to potential clinical relevance-a comprehensive narrative review.Frontiers in dental medicine · 2026Review
- Clinical performance of different composite materials in class II cavities bonded with universal adhesives.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Article
- Association Between Dietary Selenium Intake and Kidney Stones Disease Among Patients with Metabolic Syndrome: A Cross-Sectional Study from the NHANES Database.Journal of multidisciplinary healthcare · 2024Article
- Investigation of the Impact of Dental Care via Composite Resin Restoration among Children with Attention Deficit Hyperactivity Disorder: A Registry-Based Nested Case-Control Study.Healthcare (Basel, Switzerland) · 2021Article
- Review
- Presence and leaching of bisphenol a (BPA) from dental materials.Acta biomaterialia odontologica Scandinavica · 2018Article
- Changes in urinary bisphenol A concentrations associated with placement of dental composite restorations in children and adolescents.Journal of the American Dental Association (1939) · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundResin-based dental sealants and composites contain bisphenol A-glycidyl methacrylate, a bisphenol A (BPA) derivative. The authors hypothesized that a greater number of sealants or restorations would be associated with higher urinary BPA concentrations.
methodsThe authors examined urinary BPA measurements (in nanograms per milliliter) and oral examination data for 1,001 children aged 6 to 19 years from data sets of the 2003-2004 National Health and Nutrition Examination Survey (NHANES). They categorized children according to number of occlusal sealants and number of restorations, with four categories in each of the two groups. They estimated associations by using unadjusted and adjusted tobit regression models.
resultsThe lowest quartile of BPA concentrations ranged from 0.3 ng/mL to 1.9 ng/mL, whereas the highest quartile ranged from 7.3 ng/mL to 149 ng/mL. In adjusted analysis, children with seven to 16 sealants had geometric mean BPA concentrations 25 percent higher than those of children with no sealants (95 percent confidence interval [CI], -14 percent to 82 percent; P = .23). In adjusted analysis, children with seven to 42 restorations had geometric mean BPA concentrations 20 percent higher than those of children with no restorations (95 percent CI, -6 percent to 53 percent; P = .13). Neither of these adjusted estimates was statistically significant.
conclusionsThough the findings were in the direction hypothesized, the authors did not observe a statistically significant association between a greater number of sealants or restorations and higher urinary BPA concentrations. Additional studies are needed to determine the extent of oral and systemic exposure to BPA from resin-based dental restorative materials over time. PRACTICAL IMPLICATIONS: Dentists should follow this issue carefully as it develops and as the body of evidence grows. There is insufficient evidence to change practice at this time.
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