ArticleProceedings of the National Academy of Sciences of the United States of America2014
Malaria-induced changes in host odors enhance mosquito attraction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Trial
- Machine learning-enabled chemical ecology for integrated pest management: from volatiles to field applications.Journal of insect science (Online) · 2026Review
- Making scents of mosquito lures: semiochemical attractants for adult mosquitoes.Parasites & vectors · 2026Review
- Role of microbiota in host-Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Laboratory Evaluation of Synthetic Attractants forJournal of arthropod-borne diseases · 2025Article
- Smelly communication between haemaphysalis longicornis and infected hosts with indolic odorants: A case from severe fever with thrombocytopenia syndrome virus.PLoS neglected tropical diseases · 2025Article
- Internal and external drivers interact to create highly dynamic mosquito blood-feeding behaviour.Proceedings. Biological sciences · 2024Review
- À la carte: how mosquitoes choose their blood meals.Trends in parasitology · 2024Review
- Field- and laboratory-based studies on correlates of Chlamydia trachomatis transmission by Musca sorbens: Determinants of fly-eye contact and investigations into fly carriage of elementary bodies.PLoS neglected tropical diseases · 2024Article
- Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission.Nature communications · 2024Article
- Smelly interactions: host-borne volatile organic compounds triggering behavioural responses in mosquitoes, sand flies, and ticks.Parasites & vectors · 2024Review
- The volatilome signatures of Plasmodium falciparum parasites during the intraerythrocytic development cycle in vitro under exposure to artemisinin drug.Scientific reports · 2023Article
- Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission.Malaria journal · 2023Article
- Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data.Malaria journal · 2023Article
- Immune Stimulation via Wounding Alters Chemical Profiles of Adult Tribolium castaneum.Journal of chemical ecology · 2023Article
- Traveling across Life Sciences with Acetophenone-A Simple Ketone That Has Special Multipurpose Missions.Molecules (Basel, Switzerland) · 2023Review
- Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages.Scientific reports · 2022Article
- Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels.Cell · 2022Article
- Experiment in semi-natural conditions did not confirm the influence of malaria infection on bird attractiveness to mosquitoes.Parasites & vectors · 2022Article
- Songbird preen oil odour reflects haemosporidian parasite load.Animal behaviour · 2022Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
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Abstract
Vector-borne pathogens may alter traits of their primary hosts in ways that influence the frequency and nature of interactions between hosts and vectors. Previous work has reported enhanced mosquito attraction to host organisms infected with malaria parasites but did not address the mechanisms underlying such effects. Here we document malaria-induced changes in the odor profiles of infected mice (relative to healthy individuals) over the course of infection, as well as effects on the attractiveness of infected hosts to mosquito vectors. We observed enhanced mosquito attraction to infected mice during a key period after the subsidence of acute malaria symptoms, but during which mice remained highly infectious. This attraction corresponded to an overall elevation in the volatile emissions of infected mice observed during this period. Furthermore, data analyses--using discriminant analysis of principal components and random forest approaches--revealed clear differences in the composition of the volatile blends of infected and healthy individuals. Experimental manipulation of individual compounds that exhibited altered emission levels during the period when differential vector attraction was observed also elicited enhanced mosquito attraction, indicating that compounds being influenced by malaria infection status also mediate vector host-seeking behavior. These findings provide important insights into the cues that mediate vector attraction to hosts infected with transmissible stages of malaria parasites, as well as documenting characteristic changes in the odors of infected individuals that may have potential value as diagnostic biomarkers of infection.
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