ArticleAntimicrobial agents and chemotherapy2014
Impact of third-generation-cephalosporin administration in hatcheries on fecal Escherichia coli antimicrobial resistance in broilers and layers.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Antimicrobial Resistance and Species Dynamics ofVeterinary sciences · 2026Article
- Antibiotic susceptibility of lactic acid bacteria isolated from artisanal coalho cheese in the Agreste region of Pernambuco, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Detection of carbapenem resistance among third-generation cephalosporin-resistant Enterobacterales from small-scale poultry farms in peri-urban Lusaka, Zambia.Access microbiology · 2026Article
- Antimicrobial Resistance in SelectedAntibiotics (Basel, Switzerland) · 2025Review
- Origin and development of twoMicrobial genomics · 2025Article
- Serogrouping and Molecular Characterization of ESBL-Producing Avian PathogenicAntibiotics (Basel, Switzerland) · 2025Article
- Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Commercial Day-Old Chicks in Nigeria Are Potential Reservoirs of Colistin- and Tigecycline-Resistant Potentially PathogenicAntibiotics (Basel, Switzerland) · 2024Article
- Evolution of the Antibiotic Resistance Levels, Multi-Resistance Patterns, and Presence of Antibiotic Resistance Genes inAntibiotics (Basel, Switzerland) · 2024Article
- Prevalence and Transmission of Extended-Spectrum Cephalosporin (ESC) Resistance Genes inAntibiotics (Basel, Switzerland) · 2023Article
- Impact of antimicrobial use on abundance of antimicrobial resistance genes in chicken flocks in Vietnam.JAC-antimicrobial resistance · 2023Article
- Prevalence and whole genome phylogenetic analysis reveal genetic relatedness between antibiotic resistance Salmonella in hatchlings and older chickens from farms in Nigeria.Poultry science · 2023Article
- Article
- Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small-scale chicken farms of the Mekong delta of Vietnam.Transboundary and emerging diseases · 2022Article
- Metagenomic assembly reveals hosts and mobility of common antibiotic resistome in animal manure and commercial compost.Environmental microbiome · 2022Article
- Antimicrobial resistance in Escherichia coli isolated from on-farm and conventional hatching broiler farms in Ireland.Irish veterinary journal · 2022Article
- Article
- Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- A comparison of antibiotics, antibiotic resistance genes, and bacterial community in broiler and layer manure following composting.Environmental science and pollution research international · 2021Article
- Molecular Epidemiology of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the impact of the hatchery practice of administering third-generation cephalosporin (3GC) on the selection and persistence of 3GC-resistant Escherichia coli in poultry. We studied 15 3GC-treated (TB) and 15 non-3GC-treated (NTB) broiler flocks and 12 3GC-treated (TL) and 10 non-3GC-treated (NTL) future layer flocks. Fecal samples from each flock were sampled before arrival on the farm (day 0), on day 2, on day 7, and then twice more. E. coli isolates were isolated on MacConkey agar without antibiotics and screened for 3GC resistance, and any 3GC-resistant E. coli isolates were further analyzed. 3GC-resistant E. coli isolates were found in all 3GC-treated flocks on at least one sampling date. The percentages of 3GC-resistant E. coli isolates were significantly higher in TB (41.5%) than in NTB (19.5%) flocks and in TL (49.5%) than in NTL (24.5%) flocks. In the day 2 samples, more than 80% of the E. coli strains isolated were 3GC resistant. 3GC-resistant E. coli strains were still detected at the end of the follow-up period in 6 out of 27 3GC-treated and 5 out of 25 non-3GC-treated flocks. Many 3GC-resistant E. coli strains were resistant to tetracycline, and there were significant differences in the percentages of resistance to sulfamethoxazole-trimethoprim, streptomycin, or gentamicin between treated and nontreated flocks. blaCTX-M and blaCMY-2 were the most frequently detected genes. These results clearly demonstrated that 3GC-resistant strains are introduced early in flocks and that the use of 3GC in hatcheries promotes the selection of 3GC-resistant E. coli. Measures must be implemented to avoid the spread and selection of 3GC-resistant strains.
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