ReviewPflugers Archiv : European journal of physiology2015
Sensory mechanotransduction at membrane-matrix interfaces.
Review in Pflugers Archiv : European journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- TREK channels in Mechanotransduction: a Focus on the Cardiovascular System.Frontiers in cardiovascular medicine · 2023Review
- Lack of evidence for participation of TMEM150C in sensory mechanotransduction.The Journal of general physiology · 2022Article
- Role of Muscle LIM Protein in Mechanotransduction Process.International journal of molecular sciences · 2022Review
- Mechanosignals in abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2022Review
- Molecular dynamics simulations of Piezo1 channel opening by increases in membrane tension.Biophysical journal · 2021Article
- Tumour Initiation: a Discussion on Evidence for a "Load-Trigger" Mechanism.Cell biochemistry and biophysics · 2019Review
- Evolution of acid nociception: ion channels and receptors for detecting acid.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Specialized mechanoreceptor systems in rodent glabrous skin.The Journal of physiology · 2018Article
- Advances in understanding nociception and neuropathic pain.Journal of neurology · 2018Review
- Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects.Journal of visualized experiments : JoVE · 2016Article
- Mechanotransduction of Neural Cells Through Cell-Substrate Interactions.Tissue engineering. Part B, Reviews · 2016Review
- Article
- Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension.Nature communications · 2016Article
- Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons.Nature communications · 2015Article
- Mechanically Activated Ion Channels.Neuron · 2015Review
- Mechanical systems biology of C. elegans touch sensation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- A special issue on physiological aspects of mechanosensing.Pflugers Archiv : European journal of physiology · 2015Article
- Transduction and encoding sensory information by skin mechanoreceptors.Pflugers Archiv : European journal of physiology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory cells specialized to detect extremely small mechanical changes are common to the auditory and somatosensory systems. It is widely accepted that mechanosensitive channels form the core of the mechanoelectrical transduction in hair cells as well as the somatic sensory neurons that underlie the sense of touch and mechanical pain. Here, we will review how the activation of such channels can be measured in a meaningful physiological context. In particular, we will discuss the idea that mechanosensitive channels normally occur in transmembrane complexes that are anchored to extracellular matrix components (ECM) both in vitro and in vivo. One component of such complexes in sensory neurons is the integral membrane scaffold protein STOML3 which is a robust physiological regulator of native mechanosensitive currents. In order to better characterize such channels in transmembrane complexes, we developed a new electrophysiological method that enables the quantification of mechanosensitive current amplitude and kinetics when activated by a defined matrix movement in cultured cells. The results of such studies strongly support the idea that ion channels in transmembrane complexes are highly tuned to detect movement of the cell membrane in relation to the ECM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.