ReviewNature reviews. Genetics2014
Comparative genetics of longevity and cancer: insights from long-lived rodents.
Review in Nature reviews. Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
132 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Pooled it
- Characterization of carcinogenesis resistance in Anatolian blind mole-rat mesenchymal stem cells and assessment of transcriptomic signatures.Stem cells (Dayton, Ohio) · 2026Article
- Intrinsic anti-tumorigenic properties of the skin epithelium promote cancer resistance in naked mole-rats.iScience · 2026Article
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability.Molecular biology reports · 2026Review
- Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan.Ecology and evolution · 2026Article
- "Metabolic memory" of aging: anchoring, transmission, and frontiers of transgenerational intervention.Biogerontology · 2026Review
- The road to a long lifespan in the Persian squirrel, a natural model for extended longevity: resisting free radical stress and healthy phospholipids.GeroScience · 2026Article
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- Immunological surveillance against cancer across mammals.Nature communications · 2025Article
- The implications of alternative splicing regulation for maximum lifespan.Nature communications · 2025Article
- The evolution of cancer and ageing: a history of constraint.Nature reviews. Cancer · 2025Review
- The Implications of Alternative Splicing Regulation for Maximum Lifespan.bioRxiv : the preprint server for biology · 2025Article
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- An overview of contemporary theories of ageing.Nature cell biology · 2025Review
- Limited cell-autonomous anticancer mechanisms in long-lived bats.Nature communications · 2025Article
- Multi-Omics-Based Analysis of the Effect of Longevity Genes on the Immune Relevance of Colorectal Cancer.Biomedicines · 2025Article
- Peto's paradox revisited (revisited, revisited, revisited, and revisited yet again).Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The depth of tumor hierarchy and its impact on hypertumor susceptibility.Scientific reports · 2025Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.