ArticleJournal of immunology (Baltimore, Md. : 1950)2014
IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
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- Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability.Communications biology · 2025Article
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- The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung.Journal of visualized experiments : JoVE · 2021Article
- Halogen exposure injury in the developing lung.Annals of the New York Academy of Sciences · 2020Review
- High-fat diet-induced obesity affects alpha 7 nicotine acetylcholine receptor expressions in mouse lung myeloid cells.Scientific reports · 2020Article
- Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells.Cancers · 2020Article
- Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants.Communications biology · 2020Article
- Sex-differences in LPS-induced neonatal lung injury.Scientific reports · 2019Article
- Differential Immune Activation in Fetal Macrophage Populations.Scientific reports · 2019Article
- Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis.Frontiers in neurology · 2019Article
- TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation.Journal of innate immunity · 2019Article
- A critical role for IRF5 in regulating allergic airway inflammation.Mucosal immunology · 2017Article
- Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction RepairTheranostics · 2017Article
- IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity.Clinics in perinatology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
In preterm infants, exposure to inflammation increases the risk of bronchopulmonary dysplasia, a chronic, developmental lung disease. Although macrophages are the key cells that initiate lung inflammation, less is known about lung macrophage phenotype and maturation. We hypothesized that fetal lung macrophages mature into distinct subpopulations during mouse development, and that activation could influence macrophage maturation. Expression of the fetal macrophage markers CD68, CD86, CD206, Ym1, fibrinogen-like protein 2, and indolamine-2, 3-dioxygenase was developmentally regulated, with each marker having different temporal patterns. Flow cytometry analysis showed macrophages within the fetal lung were less diverse than the distinctly separate subpopulations in newborn and adult lungs. Similar to adult alveolar macrophages, fetal lung macrophages responded to the TLR4 agonist LPS and the alternative activation cytokines IL-4 and IL-13. Using a macrophage-specific constitutively active IκB Kinase transgenic model (IKFM), we demonstrated that macrophage activation increased proinflammatory gene expression and reduced the response of fetal lung macrophages to IL-4 and IL-13. Activation also increased fetal lung macrophage proliferation. Fetal IKFM lungs contained increased percentages of more mature, CD11b(low)F4/80(high) cells that also expressed higher levels of the alternative activation markers CD204 and CD206. Development of fetal lung macrophages into mature alveolar macrophages may therefore include features of both proinflammatory and alternative activation paradigms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.