ArticleInfection and immunity2014
Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Efficiency of anthelmintic treatment and its effect on microparasite dynamics in wildInternational journal for parasitology. Parasites and wildlife · 2025Article
- Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases.Vaccines · 2025Review
- Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adultFrontiers in immunology · 2025Article
- Parasites and Microbiota: Dual Interactions and Therapeutic Perspectives.Microorganisms · 2024Review
- Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs.Scientific reports · 2024Article
- Infection with soil-transmitted helminths and their impact on coinfections.Frontiers in parasitology · 2023Review
- Chronic small intestinal helminth infection perturbs bile acid homeostasis and disrupts bile acid signaling in the murine small intestine.Frontiers in parasitology · 2023Article
- Co- and polymicrobial infections in the gut mucosa: The host-microbiota-pathogen perspective.Cellular microbiology · 2021Review
- A Complex Proteomic Response of the Parasitic Nematode Anisakis simplex s.s. to Escherichia coliLipopolysaccharide.Molecular & cellular proteomics : MCP · 2021Article
- Reduction ofJournal of parasitology research · 2021Article
- Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge.PLoS neglected tropical diseases · 2021Article
- Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins.International journal of molecular sciences · 2020Article
- Parasite-bacteria interrelationship.Parasitology research · 2020Review
- The gut microbiota response to helminth infection depends on host sex and genotype.The ISME journal · 2020Article
- Article
- Indigo Naturalis Alleviates Dextran Sulfate Sodium-Induced Colitis in Rats via Altering Gut Microbiota.Frontiers in microbiology · 2020Article
- Helminth-Induced and Th2-Dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High-Fat Diet.Cellular and molecular gastroenterology and hepatology · 2020Article
- Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace.Scientific reports · 2019Article
- Metabolism at the centre of the host-microbe relationship.Clinical and experimental immunology · 2019Review
- Associations between soil-transmitted helminthiasis and viral, bacterial, and protozoal enteroinfections: a cross-sectional study in rural Laos.Parasites & vectors · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Salmonella enterica serovar Typhimurium is a Gram-negative food-borne pathogen that is a major cause of acute gastroenteritis in humans. The ability of the host to control such bacterial pathogens may be influenced by host immune status and by concurrent infections. Helminth parasites are of particular interest in this context because of their ability to modulate host immune responses and because their geographic distribution coincides with those parts of the world where infectious gastroenteritis is most problematic. To test the hypothesis that helminth infection may negatively regulate host mucosal innate immunity against bacterial enteropathogens, a murine coinfection model was established by using the intestinal nematode Heligmosomoides polygyrus and S. Typhimurium. We found that mice coinfected with S. Typhimurium and H. polygyrus developed more severe intestinal inflammation than animals infected with S. Typhimurium alone. The enhanced susceptibility to Salmonella-induced intestinal injury in coinfected mice was found to be associated with diminished neutrophil recruitment to the site of bacterial infection that correlated with decreased expression of the chemoattractants CXCL2/macrophage inflammatory protein 2 (MIP-2) and CXCL1/keratinocyte-derived chemokine (KC), poor control of bacterial replication, and exacerbated intestinal inflammation. The mechanism of helminth-induced inhibition of MIP-2 and KC expression involved interleukin-10 (IL-10) and, to a lesser extent, IL-4 and IL-13. Ly6G antibody-mediated depletion of neutrophils reproduced the adverse effects of H. polygyrus on Salmonella infection. Our results suggest that impaired neutrophil recruitment is an important contributor to the enhanced severity of Salmonella enterocolitis associated with helminth coinfection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.