ArticleInfection and immunity2014
The AgrD N-terminal leader peptide of Staphylococcus aureus has cytolytic and amyloidogenic properties.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Article
- Determinants of maturation of theJournal of bacteriology · 2024Article
- Quorum-sensing, intra- and inter-species competition in the staphylococci.Microbiology (Reading, England) · 2023Review
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
- Differential fibril morphologies and thermostability determine functional roles ofFrontiers in molecular biosciences · 2023Article
- Conformational analysis and interaction of theFrontiers in chemistry · 2023Article
- Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Biological Functions of Prokaryotic Amyloids in Interspecies Interactions: Facts and Assumptions.International journal of molecular sciences · 2020Review
- Amyloidogenic Peptides in Human Neuro-Degenerative Diseases and in Microorganisms: A Sorrow Shared Is a Sorrow Halved?Molecules (Basel, Switzerland) · 2020Review
- Phenol-Soluble Modulins Modulate Persister Cell Formation inFrontiers in microbiology · 2020Article
- From Staphylococcus aureus gene regulation to its pattern formation.Journal of mathematical biology · 2019Article
- The Role of Functional Amyloids in Bacterial Virulence.Journal of molecular biology · 2018Review
- Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptides.Nature communications · 2018Article
- A Systematic Evaluation of the Two-Component Systems Network Reveals That ArlRS Is a Key Regulator of Catheter Colonization byFrontiers in microbiology · 2018Article
- Surfaceome and Proteosurfaceome in Parietal Monoderm Bacteria: Focus on Protein Cell-Surface Display.Frontiers in microbiology · 2018Review
- Therapeutic Targeting of theFrontiers in microbiology · 2018Review
- Defining motility in the Staphylococci.Cellular and molecular life sciences : CMLS · 2017Review
- Amyloid Structures as Biofilm Matrix Scaffolds.Journal of bacteriology · 2016Review
- Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.Cell chemical biology · 2016Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus virulence is coordinated through the Agr quorum-sensing system to produce an array of secreted molecules. One important class of secreted virulence factors is the phenol-soluble modulins (PSMs). PSMs are small-peptide toxins that have recently been characterized for their roles in infection, biofilm development, and subversion of the host immune system. In this work, we demonstrate that the signal peptide of the S. aureus quorum-sensing signal, AgrD, shares structural and functional similarities with the PSM family of toxins. The efficacy of this peptide (termed N-AgrD) beyond AgrD propeptide trafficking has never been described before. We observe that N-AgrD, like the PSMs, is found in the amyloid fibrils of S. aureus biofilms and is capable of forming and seeding amyloid fibrils in vitro. N-AgrD displays cytolytic and proinflammatory properties that are abrogated after fibril formation. These data suggest that the N-AgrD leader peptide affects S. aureus biology in a manner similar to that described previously for the PSM peptide toxins. Taken together, our findings suggest that peptide cleavage products can affect cellular function beyond their canonical roles and may represent a class of virulence factors warranting further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.