ArticleTissue engineering. Part C, Methods2015
Predicting in vivo responses to biomaterials via combined in vitro and in silico analysis.
Article in Tissue engineering. Part C, Methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential.Advanced healthcare materials · 2026Review
- Application of Temporally Controlled Release Systems in Periodontal Tissue Regeneration: From Material Design to Therapeutic Strategies.Pharmaceutics · 2026Review
- Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices.Bioactive materials · 2026Article
- Histomorphologic Outcomes of GalaFLEX Scaffold Used in Breast Surgery: Clinical Follow-up From 6 Weeks to 63 Months.Aesthetic surgery journal · 2025Article
- Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis.PLoS computational biology · 2024Article
- Regenerative medicine meets mathematical modelling: developing symbiotic relationships.NPJ Regenerative medicine · 2021Review
- Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior.Annals of biomedical engineering · 2020Article
- The Role of In Vitro Immune Response Assessment for Biomaterials.Journal of functional biomaterials · 2019Review
- The choice of cryopreservation method affects immune compatibility of human cardiovascular matrices.Scientific reports · 2017Article
- Braided and Stacked Electrospun Nanofibrous Scaffolds for Tendon and Ligament Tissue Engineering.Tissue engineering. Part A · 2017Article
- Biomaterial-driven in situ cardiovascular tissue engineering-a multi-disciplinary perspective.NPJ Regenerative medicine · 2017Review
- Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.Journal of critical care · 2016Article
- Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- The Effect of Biomaterials Used for Tissue Regeneration Purposes on Polarization of Macrophages.BioResearch open access · 2016Review
- Extracellular Matrix-Based Biohybrid Materials for Engineering Compliant, Matrix-Dense Tissues.Advanced healthcare materials · 2015Review
- Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.Journal of biomedical materials research. Part A · 2015Article
- Molecular Characterization of Macrophage-Biomaterial Interactions.Advances in experimental medicine and biology · 2015Review
- Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling.Frontiers in immunology · 2015Article
- Impact of chemically-modified tetracycline 3 on intertwined physiological, biochemical, and inflammatory networks in porcine sepsis/ARDS.International journal of burns and trauma · 2015Article
- Rethinking regenerative medicine: a macrophage-centered approach.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The host response to both synthetic and biologically derived biomaterials is a temporally regulated, complex process that involves multiple interacting cell types. This complexity has classically limited the efficacy of in vitro assays for predicting the in vivo outcome, necessitating the use of costly animal models for biomaterial development. The present study addressed these challenges by developing an in vitro assay that characterized the dynamic inflammatory response of human monocyte-derived-macrophages to biomaterials, coupled with quasi-mechanistic analysis in silico analysis: principal component analysis (PCA) and dynamic network analysis (DyNA). Synthetic and extracellular matrix (ECM)-derived materials were evaluated using this method, and were then associated with the in vivo remodeling and macrophage polarization response in a rodent skeletal muscle injury model. PCA and DyNA revealed a distinct in vitro macrophage response to ECM materials that corresponded to constructive remodeling and an increased M2 macrophage presence in vivo. In contrast, PCA and DyNA suggested a response to crosslinked ECM and synthetic materials characteristic of a foreign body reaction and dominant M1 macrophage response. These results suggest that in silico analysis of an in vitro macrophage assay may be useful as a predictor for determining the in vivo host response to implanted biomaterials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.