ArticleThe EMBO journal1989
Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.Cellular and molecular life sciences : CMLS · 2024Article
- Non-muscle myosin 2 at a glance.Journal of cell science · 2023Review
- Insights and perspectives on the enigmatic alary muscles of arthropods.Frontiers in cell and developmental biology · 2023Review
- Review
- A role for actomyosin contractility in Notch signaling.BMC biology · 2019Article
- Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.Annual review of cell and developmental biology · 2017Review
- Force transmission in epithelial tissues.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis.PloS one · 2015Article
- The actomyosin machinery is required for Drosophila retinal lumen formation.PLoS genetics · 2014Article
- A cDNA microarray, UniShrimpChip, for identification of genes relevant to testicular development in the black tiger shrimp (Penaeus monodon).BMC molecular biology · 2011Article
- Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis.Developmental biology · 2010Article
- Actomyosin purse strings: renewable resources that make morphogenesis robust and resilient.HFSP journal · 2008Article
- Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis.Genetics · 1998Article
- Essential light chain of Drosophila nonmuscle myosin II.Journal of muscle research and cell motility · 1995Article
- An unconventional myosin heavy chain gene from Drosophila melanogaster.The Journal of cell biology · 1992Article
- Myosin functional domains encoded by alternative exons are expressed in specific thoracic muscles of Drosophila.The Journal of cell biology · 1991Article
- Actin in the Drosophila embryo: is there a relationship to developmental cue localization?BioEssays : news and reviews in molecular, cellular and developmental biology · 1991Review
- Localization of a myosin heavy chain-like polypeptide to Drosophila nuclear pore complexes.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin.The Journal of cell biology · 1990Article
- Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In contrast to vertebrate species Drosophila has a single myosin heavy chain gene that apparently encodes all sarcomeric heavy chain polypeptides. Flies also contain a cytoplasmic myosin heavy chain polypeptide that by immunological and peptide mapping criteria is clearly different from the major thoracic muscle isoform. Here, we identify the gene that encodes this cytoplasmic isoform and demonstrate that it is distinct from the muscle myosin heavy chain gene. Thus, fly myosin heavy chains are the products of a gene family. Our data suggest that the contractile function required to power myosin based movement in non-muscle cells requires myosin diversity beyond that available in a single heavy chain gene. In addition, we show, that accumulation of cytoplasmic myosin transcripts is regulated in a developmental stage specific fashion, consistent with a key role for this protein in the movements of early embryogenesis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.