Evidence map›Paper›PMID 24980687›Full record

ArticleInternational journal of colorectal disease2014

Long-term results after proactive management for locoregional control in patients with colonic cancer at high risk of peritoneal metastases.

P Sammartino, S Sibio, D Biacchi, M Cardi, P Mingazzini, M S Rosati, T Cornali, B Sollazzo, J Maherfouad Atta, A Di Giorgio

Registry-linked trialAbstract read
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In one paragraph

Article in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02974556 (Proactive Management of Endoperitoneal Spread in Colonic Cancer), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02974556 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Proactive Management of Endoperitoneal Spread in Colonic Cancer

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2024 to 2025Enrolled140ConditionsColon Cancer, Intraperitoneal Rectal CancerArmsStandard surgical treatment, Proactive management, Standard adjuvant systemic chemotherapy
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

P SammartinoDepartment of Surgery "Pietro Valdoni", Azienda Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00155, Rome, Italy, paolo.sammartino@uniroma1.it.
S Sibio
D Biacchi
M Cardi
P Mingazzini
M S Rosati
T Cornali
B Sollazzo
J Maherfouad Atta
A Di Giorgio
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA major problem in treating patients with peritoneal spread from colorectal cancer is that at diagnosis wide peritoneal involvement often precludes all curative attempts. A possible solution is to identify those patients at risk for peritoneal metastases and intervene early to prevent locoregional disease spread before it develops and, thus, to improve outcome.

methodsWe analyzed long-term results from a previous study and compared outcomes in 25 patients with advanced colon cancer considered at high risk for peritoneal spread (pT3/pT4 and mucinous or signet ring cell histology) prospectively included and managed with a proactive surgical approach including target organ resection for peritoneal spread plus hyperthermic intraperitoneal chemotherapy (HIPEC) and in 50 retrospectively well-matched controls who underwent standard surgical resection during the same period and in the same hospital by different surgical teams.

resultsAt 48 months after the study closed, peritoneal metastases and local recurrence developed significantly less often in proactively managed patients than in controls (4 vs 28%) (p < 0.03). Patients in the proactive group also survived longer than control patients (median overall survival 59.5 vs 52 months). Despite similar morbidity, Kaplan-Meier survival curves disclosed significantly longer disease-free and overall survival in the proactive than in the control group (p < 0.05 and <0.04).

conclusionsIn patients with advanced colon cancer at risk for peritoneal recurrence, the proactive surgical approach plus HIPEC seems to achieve good locoregional control preventing peritoneal spread thus improving outcome without increasing morbidity. These advantages merit investigation in a multicentric randomized trial.

Indexed as

AgedAntineoplastic AgentsCase-Control StudiesChemotherapy, AdjuvantColonic NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHumansHyperthermia, InducedMaleMiddle AgedNeoplasm Recurrence, LocalOrganoplatinum CompoundsOxaliplatinPeritoneal NeoplasmsAntineoplastic AgentsOrganoplatinum CompoundsOxaliplatin

Identifiers

PMID24980687
OpenAlexW2075794939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.