Evidence map›Paper›PMID 24980489›Full record

Trial reportEuropean heart journal2014

Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction.

Mauro Gori, Michele Senni, Deepak K Gupta, David M Charytan, Elisabeth Kraigher-Krainer, Burkert Pieske, Brian Claggett, Amil M Shah, Angela B S Santos, Michael R Zile and 7 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03837470 (Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03837470 early_phase1completednot on this mapstarted 2019, after this paper: background citation

Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction

TypeinterventionalSponsorAdhish AgarwalRan2019 to 2020Enrolled14ConditionsHeart Failure With Preserved Ejection FractionArms0.9% Sodium Chloride, Furosemide 40 mg
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
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  6. Observational
  7. Observational
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  9. ANMCO position paper: diagnosis and treatment of heart failure with preserved systolic function.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  10. Observational
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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  17. Review
  18. Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 5 countries.

Mauro GoriDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis St, Boston 02445, MA, USA.
Michele SenniCardiovascular Department, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
Deepak K GuptaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis St, Boston 02445, MA, USA.
David M CharytanRenal Division and Clinical Biometrics, Brigham and Women's Hospital, Boston, MA, USA.
Elisabeth Kraigher-KrainerMedical University Graz, Graz, Austria.
Burkert PieskeMedical University Graz, Graz, Austria.
Brian ClaggettDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis St, Boston 02445, MA, USA.
Amil M ShahDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis St, Boston 02445, MA, USA.
Angela B S SantosDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis St, Boston 02445, MA, USA.
Michael R ZileMedical University of South Carolina, Charleston, SC, USA U.S. Department of Veterans Affairs, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
Adriaan A VoorsUniversity of Groningen, Groningen, The Netherlands.
John J V McMurrayUniversity of Glasgow, Glasgow, UK.
Milton PackerUniversity of Texas Southwestern, Dallas, TX, USA.
Toni BransfordNovartis Pharmaceuticals, East Hanover, NJ, USA.
Martin LefkowitzNovartis Pharmaceuticals, East Hanover, NJ, USA.
Scott D SolomonDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis St, Boston 02445, MA, USA ssolomon@rics.bwh.harvard.edu.
PARAMOUNT Investigators
Brigham and Women's Hospital · USMedical University of Graz · ATNovartis (United States) · USOspedale Papa Giovanni XXIII · ITRalph H. Johnson VA Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of Glasgow · GBUniversity of Groningen · NL

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
Systolic & diastolic dysfunction in heart failure and preserved ejection fractionK08HL116792 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAH, AMIL M · 2013 to 2017
$735k
NHLBI NIH HHS K08 HL116792NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

aimRenal dysfunction is a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). We sought to determine whether renal dysfunction was associated with measures of cardiovascular structure/function in patients with HFpEF.

methodsWe studied 217 participants from the PARAMOUNT study with HFpEF who had echocardiography and measures of kidney function. We evaluated the relationships between renal dysfunction [estimated glomerular filtration rate (eGFR) >30 and <60 mL/min/1.73 m(2) and/or albuminuria] and cardiovascular structure/function.

resultsThe mean age of the study population was 71 years, 55% were women, 94% hypertensive, and 40% diabetic. Impairment of at least one parameter of kidney function was present in 62% of patients (16% only albuminuria, 23% only low eGFR, 23% both). Renal dysfunction was associated with abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) (adjusted P = 0.048), lower midwall fractional shortening (MWFS) (P = 0.009), and higher NT-proBNP (P = 0.006). Compared with patients without renal dysfunction, those with low eGFR and no albuminuria had a higher prevalence of abnormal LV geometry (P = 0.032) and lower MWFS (P < 0.01), as opposed to those with only albuminuria. Conversely, albuminuria alone was associated with greater LV dimensions (P < 0.05). Patients with combined renal impairment had mixed abnormalities (higher LV wall thicknesses, NT-proBNP; lower MWFS).

conclusionRenal dysfunction, as determined by both eGFR and albuminuria, is highly prevalent in HFpEF, and associated with cardiac remodelling and subtle systolic dysfunction. The observed differences in cardiac structure/function between each type of renal damage suggest that both parameters of kidney function might play a distinct role in HFpEF.

Indexed as

AgedAlbuminuriaCardio-Renal SyndromeCreatinineEchocardiographyFemaleGlomerular Filtration RateHumansHypertrophy, Left VentricularMaleProspective StudiesStroke VolumeCreatinineAlbuminuriaCardiovascular structure and functionChronic kidney diseaseGlomerular filtration rateHeart failure with preserved ejection fraction

Identifiers

PMID24980489
PMCPMC4810804
OpenAlexW2166074631

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.