ArticleBMC cardiovascular disorders2014
Impact of adiposity on cardiac structure in adult life: the Childhood Determinants of Adult Health (CDAH) study.
Article in BMC cardiovascular disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Childhood obesity and its physical and psychological co-morbidities: a systematic review of Australian children and adolescents.European journal of pediatrics · 2015Pooled it
- Adulthood adiposity affects cardiac structure and function in later life.European heart journal · 2024Article
- Association Between Risk Factors in Childhood and Sex Differences in Prevalence of Carotid Artery Plaques and Intima-Media Thickness in Mid-Adulthood in the Childhood Determinants of Adult Health Study.Journal of the American Heart Association · 2023Article
- A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure.PLoS biology · 2022Article
- Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment.Frontiers in pediatrics · 2022Article
- Early growth outcomes in very low birth weight infants with bronchopulmonary dysplasia or fetal growth restriction.Pediatric research · 2020Article
- Trends and Prevalence of Overweight and Obesity among Children Aged 2-7 Years from 2011 to 2017 in Xiamen, China.Obesity facts · 2019Article
- Plasma adrenomedullin level in children with obesity: relationship to left ventricular function.World journal of pediatrics : WJP · 2018Article
- Associations of childhood and adult obesity with left ventricular structure and function.International journal of obesity (2005) · 2017Article
- Birthweight, childhood growth and left ventricular structure at age 60-64 years in a British birth cohort study.International journal of epidemiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.
methodsThe Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.
resultsThere was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.
conclusionsAdiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.
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Registered trials
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