Trial reportSleep medicine2014
Age-related changes in slow wave activity rise time and NREM sleep EEG with and without zolpidem in healthy young and older adults.
Trial report in Sleep medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Age-dependent electroencephalogram alterations under remimazolam anesthesia.Korean journal of anesthesiology · 2026Observational
- Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers.Aging cell · 2026Article
- Sleep alterations as a function of 88 health indicators.BMC medicine · 2024Article
- The GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Novel methods for elucidating modality importance in multimodal electrophysiology classifiers.Frontiers in neuroinformatics · 2023Article
- Protocol for single case experimental design for yoga and sleep quality and inflammation: A two-hit model of sleep intervention.Contemporary clinical trials communications · 2022Article
- Article
- New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences.Frontiers in neuroscience · 2021Review
- Spectral and Entropic Features Are Altered by Age in the Electroencephalogram in Patients under Sevoflurane Anesthesia.Anesthesiology · 2020Article
- Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep.Current biology : CB · 2019Article
- Article
- Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease.Science translational medicine · 2019Observational
- Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies.Current sleep medicine reports · 2017Article
- The effect of nonbenzodiazepines sedative hypnotics on apnea-hypopnea index: A meta-analysis.Annals of thoracic medicineArticle
- Insomnia and Mild Cognitive Impairment.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWhether there are age-related changes in slow wave activity (SWA) rise time, a marker of homeostatic sleep drive, is unknown. Additionally, although sleep medication use is highest among older adults, the quantitative electroencephalographic (EEG) profile of the most commonly prescribed sleep medication, zolpidem, in older adults is also unknown. We therefore quantified age-related and regional brain differences in sleep EEG with and without zolpidem.
methodsThirteen healthy young adults aged 21.9 ± 2.2 years and 12 healthy older adults aged 67.4 ± 4.2 years participated in a randomized, double-blind, within-subject study that compared placebo to 5 mg zolpidem.
resultsOlder adults showed a smaller rise in SWA and zolpidem increased age-related differences in SWA rise time such that age differences were observed earlier after latency to persistent sleep. Age-related differences in EEG power differed by brain region. Older, but not young, adults showed zolpidem-dependent reductions in theta and alpha frequencies. Zolpidem decreased stage 1 in older adults and did not alter other age-related sleep architecture parameters.
conclusionsSWA findings provide additional support for reduced homeostatic sleep drive or reduced ability to respond to sleep drive with age. Consequences of reduced power in theta and alpha frequencies in older adults remain to be elucidated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.