ArticleProceedings of the National Academy of Sciences of the United States of America2014
Seasonal induction of GABAergic excitation in the central mammalian clock.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Inter-hemispheric connections modulate splitting in a computational model of the bilateral SCN.bioRxiv : the preprint server for biology · 2026Article
- A GABAergic network from AVP- to VIP-neurons in the suprachiasmatic nucleus sets the timing of circadian behavior rhythms.PLoS biology · 2026Article
- E4BP4-Driven Circadian SLC6A1 Expression Governs Tiagabine Chronoefficacy in Temporal Lobe Epilepsy.Molecular neurobiology · 2025Article
- Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications.Annals of medicine · 2025Review
- The effects of diazepam on sleep depend on the photoperiod.Acta pharmacologica Sinica · 2025Article
- Beyond vision: effects of light on the circadian clock and mood-related behaviours.Npj biological timing and sleep · 2025Review
- Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice.Journal of biological rhythms · 2024Article
- One seasonal clock fits all?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Circadian Rhythm Regulation by Pacemaker Neuron Chloride Oscillation in Flies.Physiology (Bethesda, Md.) · 2024Review
- Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The influence of season on glutamate and GABA levels in the healthy human brain investigated by magnetic resonance spectroscopy imaging.Human brain mapping · 2023Article
- Aging affects GABAergic function and calcium homeostasis in the mammalian central clock.Frontiers in neuroscience · 2023Article
- Chronic exposure to dim light at night disrupts cell-mediated immune response and decreases longevity in aged female mice.Chronobiology international · 2022Article
- Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway.iScience · 2022Article
- Iterative Metaplasticity Across Timescales: How Circadian, Ultradian, and Infradian Rhythms Modulate Memory Mechanisms.Journal of biological rhythms · 2022Review
- Long-Term Imaging Reveals a Circadian Rhythm of Intracellular Chloride in Neurons of the Suprachiasmatic Nucleus.Journal of biological rhythms · 2022Article
- Modelling the functional roles of synaptic and extra-synaptic γ-aminobutyric acid receptor dynamics in circadian timekeeping.Journal of the Royal Society, Interface · 2021Article
- Role of the cation-chloride-cotransporters in the circadian system.Asian journal of pharmaceutical sciences · 2021Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The balance between excitation and inhibition is essential for the proper function of neuronal networks in the brain. The inhibitory neurotransmitter γ-aminobutyric acid (GABA) contributes to the network dynamics within the suprachiasmatic nucleus (SCN), which is involved in seasonal encoding. We investigated GABAergic activity and observed mainly inhibitory action in SCN neurons of mice exposed to a short-day photoperiod. Remarkably, the GABAergic activity in a long-day photoperiod shifts from inhibition toward excitation. The mechanistic basis for this appears to be a change in the equilibrium potential of GABA-evoked current. These results emphasize that environmental conditions can have substantial effects on the function of a key neurotransmitter in the central nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.