Evidence map›Paper›PMID 24979389›Full record

ArticleZebrafish2014

Growth and maturation in the zebrafish, Danio rerio: a staging tool for teaching and research.

Corinna Singleman, Nathalia G Holtzman

Abstract read
In one paragraph

Article in Zebrafish, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Transient fetal hyperglycemia reprograms adipogenesis, lipogenesis, and insulin signaling in zebrafish.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  8. Article
  9. Aquatic Advancements: Refining and Validating a Zebrafish Survival Blood Collection Technique.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. The Microbiota Shapes Central Nervous System Myelination in Early Life.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  18. Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Corinna Singleman1 Department of Biology, Queens College, City University of New York , Queens, New York.
Nathalia G Holtzman

Funding

Origins and Patterning of the EpicardiumR03HD055399 · NICHD · QUEENS COLLEGE · PI GLICKMAN HOLTZMAN, NATHALIA SARAH · 2009 to 2010
$151k
Howard Hughes Medical InstituteNICHD NIH HHS R03 HD055399
6 · The paper itself

Abstract

Zebrafish have been increasingly used as a teaching tool to enhance the learning of many biological concepts from genetics, development, and behavior to the understanding of the local watershed. Traditionally, in both research and teaching, zebrafish work has focused on embryonic stages; however, later stages, from larval through adulthood, are increasingly being examined. Defining developmental stages based on age is a problematic way to assess maturity, because many environmental factors, such as temperature, population density, and water quality, impact growth and maturation. Fish length and characterization of key external morphological traits are considered better markers for maturation state. While a number of staging series exist for zebrafish, here we present a simplified normalization table of post-embryonic maturation well suited to both educational and research use. Specifically, we utilize fish size and four easily identified external morphological traits (pigment pattern, tail fin, anal fin, and dorsal fin morphology) to describe three larval stages, a juvenile stage, and an adult stage. These simplified maturation standards will be a useful tool for both educational and research protocols.

Indexed as

PigmentationAnimal FinsAnimalsEnvironmental HealthResearchZebrafish

Identifiers

PMID24979389
PMCPMC4108942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.