Evidence map›Paper›PMID 24979369›Full record

ReviewCurrent opinion in otolaryngology & head and neck surgery2014

Update in facial nerve paralysis: tissue engineering and new technologies.

Nicholas B Langhals, Melanie G Urbanchek, Amrita Ray, Michael J Brenner

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in otolaryngology & head and neck surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

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  17. The effective stimulating pulse for restoration of blink function in unilateral facial nerve paralysis rabbits, verified by a simple FES system.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016
    Article
  18. Overview of Facial Plastic Surgery and Current Developments.Surgery journal (New York, N.Y.) · 2016
    Review
  19. Facial nerve paralysis in children.World journal of clinical cases · 2015
    Article
  20. Vitamin D3 potentiates myelination and recovery after facial nerve injury.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Nicholas B LanghalsaSection of Plastic Surgery, Department of Surgery bDepartment of Biomedical Engineering cDivision of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA *Nicholas B. Langhals and Melanie G. Urbanchek contributed equally to the writing of this article.
Melanie G Urbanchek
Amrita Ray
Michael J Brenner
Plastic Surgery Hospital · CNUniversity of Michigan–Ann Arbor · US

Funding

Advanced Research Training in OtolaryngologyT32DC005356 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORFAS, GABRIEL · 2002 to 2021
$3.5M
Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect HearingK08DC012535 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, MICHAEL J. · 2012 to 2016
$1.2M
NIDCD NIH HHS 1K08DC012535NIDCD NIH HHS K08 DC012535NIDCD NIH HHS T32 DC005356
6 · The paper itself

Abstract

purpose of reviewTo present the recent advances in the treatment of facial paralysis, emphasizing the emerging technologies. This review will summarize the current state of the art in the management of facial paralysis and discuss the advances in nerve regeneration, facial reanimation, and use of novel biomaterials. This review includes surgical innovations in reinnervation and reanimation as well as progress with bioelectrical interfaces. RECENT

findingsThe last decade has witnessed major advances in the understanding of nerve injury and approaches for management. Key innovations include strategies to accelerate nerve regeneration, provide tissue-engineered constructs that may replace nonfunctional nerves, approaches to influence axonal guidance, limiting of donor-site morbidity, and optimization of functional outcomes. Approaches to muscle transfer continue to evolve, and new technologies allow for electrical nerve stimulation and use of artificial tissues. SUMMARY: The fields of biomedical engineering and facial reanimation increasingly intersect, with innovative surgical approaches complementing a growing array of tissue engineering tools. The goal of treatment remains the predictable restoration of natural facial movement, with acceptable morbidity and long-term stability. Advances in bioelectrical interfaces and nanotechnology hold promise for widening the window for successful treatment intervention and for restoring both lost neural inputs and muscle function.

Indexed as

Tissue EngineeringElectric Stimulation TherapyFacial ExpressionFacial ParalysisHumansNerve RegenerationNerve TransferNeuronal PlasticityTissue Scaffolds

Identifiers

PMID24979369
PMCPMC4171729
OpenAlexW2073652127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.