ArticlePediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association2014
Feasibility and initial effectiveness of home exercise during maintenance therapy for childhood acute lymphoblastic leukemia.
Article in Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Nutrition and physical activity interventions delivered to children and young people during cancer treatment: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- A Systematic Review of Telehealth-Based Pediatric Cancer Rehabilitation Interventions on Disability.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2024Pooled it
- Physical and functional performance assessment in pediatric oncology: a systematic review.Pediatric research · 2022Pooled it
- Effect of Home- and Community-Based Physical Activity Interventions on Physical Function Among Cancer Survivors: A Systematic Review and Meta-Analysis.Archives of physical medicine and rehabilitation · 2017Pooled it
- Parental involvement in exercise and diet interventions for childhood cancer survivors: a systematic review.Pediatric research · 2016Pooled it
- Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia.Pediatric blood & cancer · 2018Trial
- Physical Therapy Is an Underutilized Health Resource for Children with Cancer: A Retrospective Study Identifies Facilitators for Improvement.Healthcare (Basel, Switzerland) · 2025Article
- Exploring childhood cancer survivor, parent, healthcare and community professionals' experiences of, and priorities for, using digital health to engage in physical activity: a mixed methods study.Journal of cancer survivorship : research and practice · 2025Article
- Behavioral health interventions for pediatric acute lymphoblastic leukemia: a scoping review.Frontiers in oncology · 2025Review
- Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer:JACC. CardioOncology · 2024Review
- Physiotherapy Methods Applied in the Prevention of Functional Loss Associated with Human T-Lymphotropic Virus 1 Infection: An Overview.Infectious disease reports · 2023Review
- Effects of Exercise and Physical Activity Levels on Childhood Cancer: An Umbrella Review.Healthcare (Basel, Switzerland) · 2023Review
- Functioning of Children and Adolescents with Cancer.International journal of environmental research and public health · 2022Observational
- Exercise intervention decreases acute and late doxorubicin-induced cardiotoxicity.Cancer medicine · 2021Article
- Review
- Oncological Children and Well-Being: Occupational Performance and HRQOL Change after Fine Motor Skills Stimulation Activities.Pediatric reports · 2021Article
- Home-Based Telehealth Exercise Intervention in Early-On Survivors of Childhood Acute Lymphoblastic Leukemia: Feasibility Study.JMIR cancer · 2021Article
- Article
- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors.Advances in experimental medicine and biology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeChildren with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for patients with ALL undergoing maintenance therapy.
methodsParticipants were aged 5 to 10 years, receiving maintenance therapy, in first remission. A 6-month home-based intervention, with written and video instruction, was supervised with weekly calls from an exercise coach. Pre- and poststudy testing addressed strength, flexibility, fitness, and motor function.
resultsSeventeen patients enrolled (participation 63%). Twelve (71%) finished the intervention, completing 81.7 ± 7.2% of prescribed sessions. Improvements of 5% or more occurred in 67% for knee and 75% for grip strength, 58% for hamstring/low-back and 83% for ankle flexibility, 75% for the 6-Minute Walk Test, and 33% for performance on the Bruininks-Oseretsky Test of Motor Proficiency Version 2.
conclusionsThis pilot study demonstrated that exercise intervention during ALL therapy is feasible and has promise for efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.