ArticleChembiochem : a European journal of chemical biology2014
Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.
Article in Chembiochem : a European journal of chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Sequential Reconstruction of Calicheamicin γAngewandte Chemie (International ed. in English) · 2025Article
- Biochemical and Structural Studies of the Carminomycin 4-Journal of natural products · 2024Article
- Normal and Aberrant Methyltransferase Activities Give Insights into the Final Steps of Dynemicin A Biosynthesis.Journal of the American Chemical Society · 2023Article
- Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis.Molecules (Basel, Switzerland) · 2016Article
- Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.BMC structural biology · 2015Article
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3 authors.
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Abstract
Although bacterial iterative type I polyketide synthases are now known to participate in the biosynthesis of a small set of diverse natural products, the subsequent downstream modification of the resulting polyketide products is poorly understood. We report the functional characterization of the putative orsellinic acid C2-O-methyltransferase, which is involved in calicheamicin biosynthesis. This study suggests that C2-O-methylation precedes C3-hydroxylation/methylation and C5-iodination and requires a coenzyme A- or acyl carrier protein-bound substrate.
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