ArticleHippocampus2014
Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model.
Article in Hippocampus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
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- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- Formation and Retrieval of Cell Assemblies in a Biologically Realistic Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Spiking Neural Networks and Hippocampal Function: A Web-Accessible Survey of Simulations, Modeling Methods, and Underlying Theories.Cognitive systems research · 2021Article
- Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits.PLoS computational biology · 2021Article
- Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons.Cell reports · 2021Article
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- Research on Network Model of Dentate Gyrus Based on Bionics.Journal of healthcare engineering · 2021Article
- Quantitative properties of a feedback circuit predict frequency-dependent pattern separation.eLife · 2020Article
- Neuronal Degeneration Impairs Rhythms Between Connected Microcircuits.Frontiers in computational neuroscience · 2020Article
- Mechanisms of memory storage in a model perirhinal network.Brain structure & function · 2017Article
- Article
- Distinct current modules shape cellular dynamics in model neurons.Neuroscience · 2016Article
- Mechanisms underlying the formation of the amygdalar fear memory trace: A computational perspective.Neuroscience · 2016Article
- Synaptic competition in the lateral amygdala and the stimulus specificity of conditioned fear: a biophysical modeling study.Brain structure & function · 2016Article
- Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit.Frontiers in synaptic neuroscience · 2016Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acetylcholine regulates memory encoding and retrieval by inducing the hippocampus to switch between pattern separation and pattern completion modes. However, both processes can introduce significant variations in the level of network activity and potentially cause a seizure-like spread of excitation. Thus, mechanisms that keep network excitation within certain bounds are necessary to prevent such instability. We developed a biologically realistic computational model of the hippocampus to investigate potential intrinsic mechanisms that might stabilize the network dynamics during encoding and retrieval. The model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in stabilizing these processes. Results showed that when CA3 was considered in isolation, inhibition solely by BCs was not sufficient to control instability. However, both inhibition by OLM cells and short-term depression at the recurrent CA3 connections stabilized the network activity. In the larger network including the dentate gyrus, the model suggested that OLM inhibition could control the network during high cholinergic levels while depressing synapses at the recurrent CA3 connections were important during low cholinergic states. Our results demonstrate that short-term plasticity is a critical property of the network that enhances its robustness. Furthermore, simulations suggested that the low and high cholinergic states can each produce runaway excitation through unique mechanisms and different pathologies. Future studies aimed at elucidating the circuit mechanisms of epilepsy could benefit from considering the two modulatory states separately.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.