Evidence map›Paper›PMID 24978612›Full record

ArticleCellular immunology2014

Glucocorticoids regulate natural killer cell function epigenetically.

Justin L Eddy, Karen Krukowski, Linda Janusek, Herbert L Mathews

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Local Effects of Steroid Hormones within the Bone Microenvironment.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Glucocorticoids and COVID-19.Pharmacological research · 2022
    Review
  20. New Insights on Effects of Glucocorticoids in Patients With SARS-CoV-2 Infection.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Justin L EddyDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 60153, USA.
Karen KrukowskiDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 60153, USA.
Linda JanusekMarcella Niehoff School of Nursing, Loyola University of Chicago, Maywood, IL 60153, USA.
Herbert L MathewsDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 60153, USA. Electronic address: hmathew@lumc.edu.
Loyola University Chicago · USUniversity of Chicago · US

Funding

Immune dysregulation by psychosocial distressR01CA134736 · NCI · LOYOLA UNIVERSITY CHICAGO · PI JANUSEK, LINDA, MATHEWS, HERBERT L. · 2010 to 2014
$2.7M
NCI NIH HHS R01 CA134736NCI NIH HHS R01-CA-134736
6 · The paper itself

Abstract

Although glucocorticoids are well known for their capacity to suppress the immune response, glucocorticoids can also promote immune responsiveness. It was the purpose of this investigation to evaluate the molecular basis for this apparent dichotomous immunologic effect. Glucocorticoid treatment of natural killer cells (NK) was shown to reduce NK cell cytolytic activity by reduction of histone promoter acetylation for perforin and granzyme B, which corresponded with reduced mRNA and protein for each. In contrast, glucocorticoid treatment increased histone acetylation at regulatory regions for interferon gamma and IL-6, as well as chromatin accessibility for each. This increase in histone acetylation was associated with increased proinflammatory cytokine mRNA and protein production upon cellular stimulation. These immunologic effects were evident at the level of the individual cell and demonstrate glucocorticoids to epigenetically reduce NK cell cytolytic activity while at the same time to prime NK cells for proinflammatory cytokine production.

Indexed as

AcetylationCell Line, TumorChromatinEpigenesis, GeneticGlucocorticoidsGranzymesHistonesHumansInflammationInterferon-gammaInterleukin-6Killer Cells, NaturalPerforinPore Forming Cytotoxic ProteinsPromoter Regions, GeneticProtein Processing, Post-TranslationalChromatinGlucocorticoidsGranzymesGZMB protein, humanHistonesIL6 protein, humanInterferon-gammaInterleukin-6PerforinPore Forming Cytotoxic ProteinsPRF1 protein, humanReceptors, CytokineRELA protein, humanRNA, MessengerTranscription Factor AP-1Transcription Factor RelAEpigeneticGlucocorticoidsGranule constituentsNatural killer cellsProinflammatory cytokines

Identifiers

PMID24978612
PMCPMC4128186
OpenAlexW1994871447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.