Evidence map›Paper›PMID 24978606›Full record

ArticleMolecular and cellular endocrinology2014

Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice.

Smita Salian-Mehta, Mei Xu, Angela Pierce, Brian Bliesner, Stuart Tobet, Margaret E Wierman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Smita Salian-MehtaDepartments of Medicine, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
Mei XuDepartments of Medicine, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
Angela PierceDepartments of Medicine, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
Brian BliesnerDepartments of Medicine, University of Colorado, School of Medicine, Aurora, CO 80045, USA.
Stuart TobetDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Margaret E WiermanDepartments of Medicine, University of Colorado, School of Medicine, Aurora, CO 80045, USA; Research Service VAMC, Denver, CO 80220, USA. Electronic address: margaret.wierman@ucdenver.edu.
University of Colorado Denver · USColorado State University · USDenver VA Medical Center · US

Funding

NOVEL FACTORS THAT REGULATE GNRH NEURONAL DEVELOPMENTR01HD031191 · NICHD · UNIVERSITY OF COLORADO DENVER · PI WIERMAN, MARGARET E · 1995 to 2010
$2.3M
RAT GNRH GENE--TISSUE SPECIFIC AND HORMONAL CONTROLSR55HD031191 · NICHD · UNIVERSITY OF COLORADO DENVER · PI WIERMAN, MARGARET E. · 1994 to 1994
–
NICHD NIH HHS HD31191NICHD NIH HHS R01 HD031191
6 · The paper itself

Abstract

Prior work has shown the importance of TAM (Tyro3, Axl, Mer) receptor tyrosine kinases in GnRH neuronal development and reproductive function. It is unclear if TAM receptor actions are dependent on ligand activation for their functional effects; thus, we characterized reproductive phenotype of ligand Growth arrest specific gene (Gas6) null mice. Gas6 null mice showed delayed vaginal opening and delayed first estrus. Animals eventually attained normal estrous cycles as adults. The GnRH neuronal population was significantly decreased in Gas6 null adults and embryos, but the final positioning of cell bodies in the hypothalamus was normal. Vaginal tissue showed up-regulation of TAM receptor mRNAs in the absence of the ligand. These data confirm that Gas6 plays a role in early GnRH neuronal development and during vaginal opening. The phenotype of Gas6 KO mice suggests that TAMs function in a ligand-dependent and independent manner to control GnRH neuron development to modulate normal reproductive function.

Indexed as

AnimalsCell MovementFemaleGrowth Arrest-Specific Protein 6ImmunohistochemistryIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutNeuronsReal-Time Polymerase Chain ReactionSexual MaturationVaginaGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and ProteinsGas6GnRH neuronsTAM family

Identifiers

PMID24978606
PMCPMC4130768
OpenAlexW2009884396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.